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    efc25 Ras guanine nucleotide exchange factor efc25 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540248, updated on 18-Sep-2024

    Summary

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    Official Symbol
    efc25
    Official Full Name
    Ras guanine nucleotide exchange factor efc25
    Primary source
    PomBase:SPBC336.03
    Locus tag
    SPOM_SPBC336.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See efc25 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2739672..2743519)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SSU rRNA dimethylase Neighboring gene ncRNA Neighboring gene DNA polymerase delta catalytic subunit Cdc6 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene ncRNA Neighboring gene ribonuclease H Rnh1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the S. pombe gene efc25+, a new putative guanine nucleotide exchange factor. Tratner I, et al. Gene, 1997 Jul 9. PMID 9256078
    2. Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Papadaki P, et al. Mol Cell Biol, 2002 Jul. PMID 12052869, Free PMC Article
    3. Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5. Nuñez I, et al. Elife, 2016 Jul 30. PMID 27474797, Free PMC Article
    4. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article
    5. Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast. Navarro FJ, et al. J Cell Sci, 2017 Dec 15. PMID 29084823, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras guanine nucleotide exchange factor efc25

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2739672..2743519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022041.3 → NP_596123.1  Ras guanine nucleotide exchange factor efc25 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596123.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USU1
      Conserved Domains (2) summary
      pfam00617
      Location:755 → 932
      RasGEF; RasGEF domain
      pfam00618
      Location:593 → 700
      RasGEF_N; RasGEF N-terminal motif
    Nucleotide Protein
    Heading Accession and Version

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