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    msc1 Swr1 complex histone demethylase subunit Msc1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541710, updated on 14-Nov-2024

    Summary

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    Official Symbol
    msc1
    Official Full Name
    Swr1 complex histone demethylase subunit Msc1
    Primary source
    PomBase:SPAC343.11c
    Locus tag
    SPOM_SPAC343.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See msc1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1658316..1663315, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UBX domain-containing protein Ubx3 Neighboring gene methylenetetrahydrofolate reductase Met11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Msc1 links dynamic Swi6/HP1 binding to cell fate determination. Lawrence RJ, et al. Proc Natl Acad Sci U S A, 2009 Jan 27. PMID 19164572, Free PMC Article
    2. A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast. Ahmed S, et al. Mol Cell Biol, 2004 May. PMID 15082762, Free PMC Article
    3. The plant homeodomain fingers of fission yeast Msc1 exhibit E3 ubiquitin ligase activity. Dul BE, et al. J Biol Chem, 2007 Jun 22. PMID 17456468
    4. Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe. Gao C, et al. Genetics, 2017 Oct. PMID 28827290, Free PMC Article
    5. Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe. Ahmed S, et al. Genetics, 2007 Nov. PMID 17947424, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Absence of Msc1 sensitizes cells to perturbations in kinetochore function, while elevating Msc1 overcomes loss of function of critical components of the kinetochore and centromere.
      Title: Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe.
    2. Msc1, is a critical factor required for proper cell fate determination in S. pombe.
      Title: Msc1 links dynamic Swi6/HP1 binding to cell fate determination.
    3. Msc1 acts through H2A.Z to promote chromosome stability and cell survival following DNA damage.
      Title: Msc1 acts through histone H2A.Z to promote chromosome stability in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    NOT enables histone demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in heterochromatin organization EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    part_of Swr1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Swr1 complex histone demethylase subunit Msc1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1658316..1663315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018864.3 → NP_593431.1  Swr1 complex histone demethylase subunit Msc1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593431.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UT79
      Conserved Domains (7) summary
      smart00545
      Location:80 → 123
      JmjN; Small domain found in the jumonji family of transcription factors
      pfam02373
      Location:513 → 628
      JmjC; JmjC domain, hydroxylase
      cd15489
      Location:299 → 342
      PHD_SF; PHD finger superfamily
      cd15518
      Location:1173 → 1217
      PHD_Ecm5p_Lid2p_like; PHD finger found in Saccharomyces cerevisiae extracellular matrix protein 5 (Ecm5p), Schizosaccharomyces pombe Lid2 complex component Lid2p, and similar proteins
      pfam02928
      Location:716 → 764
      zf-C5HC2; C5HC2 zinc finger
      pfam08429
      Location:780 → 1129
      PLU-1; PLU-1-like protein
      cl22851
      Location:1457 → 1502
      PHD_SF; PHD finger superfamily
    Nucleotide Protein
    Heading Accession and Version

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