YHC3 amino acid transporter YHC3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YHC3
Official Full Name: amino acid transporter YHC3
Primary source: SGD:S000003595
Locus tag: YJL059W
See related: AllianceGenome:SGD:S000003595; FungiDB:YJL059W; VEuPathDB:YJL059W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BTN1
Summary: Involved in L-arginine transmembrane transport; lysine transport; and regulation of intracellular pH. Located in fungal-type vacuole. Used to study neuronal ceroid lipofuscinosis 3. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 3. Orthologous to human CLN3 (CLN3 lysosomal/endosomal transmembrane protein, battenin). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Deletion of BTN1 (btn1-Delta) led to a decreased level of phosphatidylethanolamine (PtdEtn) in both mitochondrial and vacuolar membranes.
Title: BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution.
Data suggest that Btn2p, along with Btn1 and Ist2, may play a regulatory role across the cell in response to alterations in the intracellular environment.
Title: Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.
Btn1p is required for tight regulation of vacuolar pH to maintain the vacuolar luminal content and optimal activity of this organelle
Title: Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in L-arginine transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid transport	IEA Inferred from Electronic Annotation more info
involved_in lysine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
is_active_in vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

NP_012476.1

Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant