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    cwp1 geranylgeranyltransferase type 1 alpha subunit Cwp1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543143, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cwp1
    Official Full Name
    geranylgeranyltransferase type 1 alpha subunit Cwp1
    Primary source
    PomBase:SPAPB1A10.04c
    Locus tag
    SPOM_SPAPB1A10.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cwp1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (1864551..1865771, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mRNA export receptor Nxt1 Neighboring gene protein dpc13 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ATP-dependent RNA helicase Dhr1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the geranylgeranyl transferase type I from Schizosaccharomyces pombe. Arellano M, et al. Mol Microbiol, 1998 Sep. PMID 9781874
    2. The Schizosaccharomyces pombe cwg2+ gene codes for the beta subunit of a geranylgeranyltransferase type I required for beta-glucan synthesis. Díaz M, et al. EMBO J, 1993 Dec 15. PMID 8262067, Free PMC Article
    3. Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe. Yang W, et al. J Biol Chem, 2000 Jan 7. PMID 10617635
    4. A defect in protein farnesylation suppresses a loss of Schizosaccharomyces pombe tsc2+, a homolog of the human gene predisposing to tuberous sclerosis complex. Nakase Y, et al. Genetics, 2006 Jun. PMID 16624901, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to CAAX-protein geranylgeranyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to CAAX-protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to protein farnesyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein farnesyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to protein geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptide pheromone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAAX-protein geranylgeranyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAAX-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of protein farnesyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    geranylgeranyltransferase type 1 alpha subunit Cwp1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1864551..1865771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018952.3 → NP_593518.1  geranylgeranyltransferase type 1 alpha subunit Cwp1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593518.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60052
      Conserved Domains (2) summary
      COG5536
      Location:9 → 294
      BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
      pfam01239
      Location:130 → 157
      PPTA; Protein prenyltransferase alpha subunit repeat
    Nucleotide Protein
    Heading Accession and Version

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