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    NRS1 Nrs1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NRS1
    Official Full Name
    Nrs1p
    Primary source
    SGD:S000004043
    Locus tag
    YLR053C
    See related
    AllianceGenome:SGD:S000004043; FungiDB:YLR053C; VEuPathDB:YLR053C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables promoter-specific chromatin binding activity and transcription coactivator activity. Involved in cellular response to nitrogen starvation and positive regulation of transcription by RNA polymerase II. Is active in chromatin. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NRS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (248100..248426, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Fcf2p Neighboring gene Ies3p Neighboring gene Osw2p Neighboring gene SAGA complex subunit SPT8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast. Tollis S, et al. PLoS Biol, 2022 Mar. PMID 35239649, Free PMC Article
    2. The interplay between chromosome stability and cell cycle control explored through gene-gene interaction and computational simulation. Frumkin JP, et al. Nucleic Acids Res, 2016 Sep 30. PMID 27530428, Free PMC Article
    3. Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins. Fromont-Racine M, et al. Yeast, 2000 Jun 30. PMID 10900456, Free PMC Article
    4. The yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization. Atencio D, et al. G3 (Bethesda), 2014 Mar 20. PMID 24470217, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Johnston M, et al. Nature, 1997 May 29. PMID 9169871, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.
      Title: The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nitrogen starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nrs1p
    NP_013154.1
    • Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      248100..248426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181940.1 → NP_013154.1  TPA: Nrs1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013154.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY55, Q12026
      UniProtKB/TrEMBL
      A7A0V8, B3LT24, C7GQN1, C8ZD25, G2WIP6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12026.1

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