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    RPS31 ubiquitin-ribosomal 40S subunit protein S31 fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPS31
    Official Full Name
    ubiquitin-ribosomal 40S subunit protein S31 fusion protein
    Primary source
    SGD:S000004157
    Locus tag
    YLR167W
    See related
    AllianceGenome:SGD:S000004157; FungiDB:YLR167W; VEuPathDB:YLR167W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPS37; UBI3
    Summary
    Enables protein tag activity. Involved in maintenance of translational fidelity; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S); and ribosomal small subunit assembly. Located in cytoplasm. Part of cytosolic small ribosomal subunit. Orthologous to human RPS27A (ribosomal protein S27a) and RPS27AP5 (ribosomal protein S27a pseudogene 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPS31 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (498947..499405)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS5 Neighboring gene exocyst subunit SEC10 Neighboring gene Ups2p Neighboring gene Aps1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits. Lacombe T, et al. Mol Microbiol, 2009 Apr. PMID 19210616
    2. A human ubiquitin carboxyl extension protein functions in yeast. Monia BP, et al. J Biol Chem, 1990 Nov 5. PMID 2229081
    3. Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme. Misra M, et al. Structure, 2017 Jul 5. PMID 28578874
    4. A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling. Mueller PP, et al. J Biol Chem, 1998 Dec 4. PMID 9830035
    5. The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits. Fernández-Pevida A, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27422873, Free PMC Article

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae.
      Title: Interaction between Gtr2p and ribosomal Rps31p affects the incorporation of Rps31p into ribosomes of Saccharomyces cerevisiae.
    2. Deletion of the ubiquitin moiety from UBI3 led to a decrease in 40S ribosomal subunits and to the incorporation of the 20S pre-rRNA into polyribosomes.
      Title: Linear ubiquitin fusion to Rps31 and its subsequent cleavage are required for the efficient production and functional integrity of 40S ribosomal subunits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-ribosomal 40S subunit protein S31 fusion protein
    NP_013268.1
    • Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      498947..499405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182054.1 → NP_013268.1  TPA: ubiquitin-ribosomal 40S subunit protein S31 fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYH3, P05759, P14800
      UniProtKB/TrEMBL
      A7A160, B3RH62, C7GIV9, C8ZDE0, G2WJ02, N1P195
      Conserved Domains (2) summary
      cd01803
      Location:1 → 76
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
      pfam01599
      Location:103 → 146
      Ribosomal_S27; Ribosomal protein S27a
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05759.3

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