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    Ipp IAP promoted placental gene [ Mus musculus (house mouse) ]

    Gene ID: 16351, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ippprovided by MGI
    Official Full Name
    IAP promoted placental geneprovided by MGI
    Primary source
    MGI:MGI:96581
    See related
    Ensembl:ENSMUSG00000028696 AllianceGenome:MGI:96581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mipp; D4Jhu8
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and yolk sac endoderm. Orthologous to human IPP (intracisternal A particle-promoted polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 3.6), liver E14.5 (RPKM 2.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipp in Genome Data Viewer
    Location:
    4 D1; 4 53.2 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116364710..116400607)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116507512..116543410)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene phosphoinositide-3-kinase regulatory subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11136 Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene STARR-seq mESC enhancer starr_11138 Neighboring gene predicted gene, 52760 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116180277-116180386 Neighboring gene STARR-seq mESC enhancer starr_11140 Neighboring gene transmembrane protein 69 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene RIKEN cDNA C530005A16 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Frequent ectopic expression of a placenta-specific gene at high levels in BALB/c mouse mammary carcinomas. VanHouten JN, et al. Oncogene, 1996 May 16. PMID 8668351
    2. Cell lineage-specific expression of the MIPP gene. Mold DE, et al. Biochem Biophys Res Commun, 1991 Jun 28. PMID 1905535
    3. Identification of a novel murine IAP-promoted placenta-expressed gene. Chang-Yeh A, et al. Nucleic Acids Res, 1991 Jul 11. PMID 1906605, Free PMC Article
    4. The IPP gene is assigned to human chromosome 1p32-1p22. Chang-Yeh A, et al. Genomics, 1993 Jan. PMID 8432546
    5. Cloning and characterization of ectopically expressed transcripts for the actin-binding protein MIPP in mouse mammary carcinomas. VanHouten JN, et al. Oncogene, 2001 Aug 30. PMID 11536049

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding protein IPP
    Names
    intracisternal A particle-promoted polypeptide
    murine IAP-promoted placenta-expressed protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418990.1 → NP_001405919.1  actin-binding protein IPP isoform b

      Status: VALIDATED

      Source sequence(s)
      AL669953

    2. NM_001418991.1 → NP_001405920.1  actin-binding protein IPP isoform c

      Status: VALIDATED

      Source sequence(s)
      AL669953

    3. NM_001418992.1 → NP_001405921.1  actin-binding protein IPP isoform d

      Status: VALIDATED

      Source sequence(s)
      AL669953

    4. NM_001418993.1 → NP_001405922.1  actin-binding protein IPP isoform d

      Status: VALIDATED

      Source sequence(s)
      AL669953

    5. NM_008389.4 → NP_032415.2  actin-binding protein IPP isoform a

      See identical proteins and their annotated locations for NP_032415.2

      Status: VALIDATED

      Source sequence(s)
      AL669953
      Consensus CDS
      CCDS38851.1
      UniProtKB/Swiss-Prot
      P28575, Q3V2M0
      Related
      ENSMUSP00000102088.2, ENSMUST00000106479.8
      Conserved Domains (3) summary
      PHA03098
      Location:34 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116364710..116400607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502810.5 → XP_006502873.1  actin-binding protein IPP isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:34 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
      cd18466
      Location:134 → 236
      BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

    2. XM_036163740.1 → XP_036019633.1  actin-binding protein IPP isoform X2

      Conserved Domains (4) summary
      PHA03098
      Location:34 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
      cd18466
      Location:134 → 236
      BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28575.3 GenPept UniProtKB/Swiss-Prot:P28575

    Gene LinkOut

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