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    Stat1 signal transducer and activator of transcription 1 [ Mus musculus (house mouse) ]

    Gene ID: 20846, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat1provided by MGI
    Official Full Name
    signal transducer and activator of transcription 1provided by MGI
    Primary source
    MGI:MGI:103063
    See related
    Ensembl:ENSMUSG00000026104 AllianceGenome:MGI:103063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010005J02Rik
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; cell surface receptor signaling pathway via JAK-STAT; and defense response to symbiont. Acts upstream of or within several processes, including cell surface receptor signaling pathway; negative regulation of macrophage fusion; and response to exogenous dsRNA. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skeletal musculature. Used to study breast cancer and severe acute respiratory syndrome. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast carcinoma; immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 23.3), spleen adult (RPKM 19.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stat1 in Genome Data Viewer
    Location:
    1 C1.1; 1 26.81 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52158588..52201024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52119438..52161865)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene glutaminase Neighboring gene STARR-positive B cell enhancer ABC_E1992 Neighboring gene predicted gene, 31867

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II core promoter sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tumor necrosis factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood circulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-27-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-9-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metanephric mesenchymal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metanephric mesenchymal cell proliferation involved in metanephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation by virus of viral protein levels in host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of macrophage fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of metanephric nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within_positive_effect positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in renal tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cAMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cytokine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to exogenous dsRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to peptide hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to type I interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to type II interferon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type II interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type II interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ISGF3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ISGF3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal transducer and activator of transcription 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205313.1NP_001192242.1  signal transducer and activator of transcription 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC123752, AK046517, BC042551, BX513160
      Consensus CDS
      CCDS78581.1
      UniProtKB/TrEMBL
      A0A087WSP5, Q8C8M3
      Related
      ENSMUSP00000141132.2, ENSMUST00000186057.7
      Conserved Domains (5) summary
      cd10372
      Location:563713
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317572
      STAT_bind; STAT protein, DNA binding domain
      pfam12162
      Location:721745
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    2. NM_001205314.1NP_001192243.1  signal transducer and activator of transcription 1 isoform 2

      See identical proteins and their annotated locations for NP_001192243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AK039458, AK084855, BC042551, BX513160
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Related
      ENSMUSP00000140875.2, ENSMUST00000186857.7
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    3. NM_001357627.1NP_001344556.1  signal transducer and activator of transcription 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC123752
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    4. NM_009283.4NP_033309.3  signal transducer and activator of transcription 1 isoform 2

      See identical proteins and their annotated locations for NP_033309.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Variants 2, 3, and 4 encode the same isoform.
      Source sequence(s)
      AC123752, AK039458, AK082706, BC042551, BX513160
      Consensus CDS
      CCDS56628.1
      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Related
      ENSMUSP00000066743.8, ENSMUST00000070968.14
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52158588..52201024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163078.1XP_036018971.1  signal transducer and activator of transcription 1 isoform X2

      UniProtKB/TrEMBL
      Q3TW11, Q8C497, Q99K94, Q9D323
      Related
      ENSMUSP00000140518.2, ENSMUST00000186574.7
      Conserved Domains (4) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
    2. XM_017319463.3XP_017174952.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    3. XM_030252467.2XP_030108327.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    4. XM_017319464.3XP_017174953.1  signal transducer and activator of transcription 1 isoform X1

      UniProtKB/TrEMBL
      E9QK78, Q3TW11, Q8C3V4, Q9D323
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RNA

    1. XR_003954297.2 RNA Sequence

    2. XR_003954298.2 RNA Sequence