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    MUD1 Mud1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852416, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MUD1
    Official Full Name
    Mud1p
    Primary source
    SGD:S000000323
    Locus tag
    YBR119W
    See related
    AllianceGenome:SGD:S000000323; FungiDB:YBR119W; VEuPathDB:YBR119W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U1 snRNP and U2-type prespliceosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MUD1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (479338..480323)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene transketolase TKL2 Neighboring gene translation elongation factor EF-1 alpha Neighboring gene Cbp6p Neighboring gene glycine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing. Liao XC, et al. Genes Dev, 1993 Mar. PMID 8449403
    2. A broad analysis of splicing regulation in yeast using a large library of synthetic introns. Schirman D, et al. PLoS Genet, 2021 Sep. PMID 34570750, Free PMC Article
    3. Characterization of yeast U1 snRNP A protein: identification of the N-terminal RNA binding domain (RBD) binding site and evidence that the C-terminal RBD functions in splicing. Tang J, et al. RNA, 1996 Oct. PMID 8849781, Free PMC Article
    4. Mitochondrial metabolism is central for response and resistance of Saccharomyces cerevisiae to exposure to a glyphosate-based herbicide. Ravishankar A, et al. Environ Pollut, 2020 Jul. PMID 32443188
    5. Domain Requirements and Genetic Interactions of the Mud1 Subunit of the Saccharomyces cerevisiae U1 snRNP. Agarwal R, et al. G3 (Bethesda), 2019 Jan 9. PMID 30413416, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables U1 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U1 snRNA binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables U1 snRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mud1p
    NP_009677.1
    • U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      479338..480323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178467.1 → NP_009677.1  TPA: Mud1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009677.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQB7, P32605
      UniProtKB/TrEMBL
      G2W9C4, N1P9G7
      Conserved Domains (2) summary
      cd12247
      Location:225 → 295
      RRM2_U1A_like; RNA recognition motif 2 (RRM2) found in the U1A/U2B"/SNF protein family
      cl17169
      Location:61 → 112
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32605.1

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