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    Fbrs fibrosin [ Mus musculus (house mouse) ]

    Gene ID: 14123, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbrsprovided by MGI
    Official Full Name
    fibrosinprovided by MGI
    Primary source
    MGI:MGI:104648
    See related
    Ensembl:ENSMUSG00000042423 AllianceGenome:MGI:104648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbs; Fbs1
    Summary
    Enables growth factor activity. Acts upstream of or within positive regulation of fibroblast proliferation. Located in extracellular space. Orthologous to human FBRS (fibrosin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.0), spleen adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbrs in Genome Data Viewer
    Location:
    7 F3; 7 69.55 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127075925..127090685)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127478415..127491513)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20181 Neighboring gene zinc finger protein 688 Neighboring gene RIKEN cDNA B130055M24 gene Neighboring gene STARR-positive B cell enhancer ABC_E1095 Neighboring gene zinc finger protein 689 Neighboring gene STARR-seq mESC enhancer starr_20182 Neighboring gene STARR-seq mESC enhancer starr_20183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134614302-134614485 Neighboring gene STARR-positive B cell enhancer ABC_E1742 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621461-134621644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134621862-134622045 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134623956-134624143 Neighboring gene proline rich 14 Neighboring gene microRNA 7060 Neighboring gene RIKEN cDNA 1700008J07 gene Neighboring gene STARR-seq mESC enhancer starr_20184 Neighboring gene STARR-seq mESC enhancer starr_20185 Neighboring gene Snf2-related CREBBP activator protein Neighboring gene small nucleolar RNA, H/ACA box 30

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Prakash S, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892239, Free PMC Article
    2. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable fibrosin-1
    Names
    fibrosin-1
    probable fibrosin-1 long transcript protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010183.2 → NP_034313.2  probable fibrosin-1

      Status: VALIDATED

      Source sequence(s)
      AC136146
      Consensus CDS
      CCDS52408.2
      UniProtKB/TrEMBL
      A0A1N9PTV1
      Related
      ENSMUSP00000145783.3, ENSMUST00000205432.3
      Conserved Domains (1) summary
      pfam15336
      Location:602 → 782
      Auts2; Autism susceptibility gene 2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127075925..127090685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507348.5 → XP_006507411.1  probable fibrosin-1 isoform X1

      Conserved Domains (1) summary
      pfam15336
      Location:581 → 781
      Auts2; Autism susceptibility gene 2 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R089.2 GenPept UniProtKB/Swiss-Prot:Q8R089

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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