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    Rnf130 ring finger protein 130 [ Mus musculus (house mouse) ]

    Gene ID: 59044, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf130provided by MGI
    Official Full Name
    ring finger protein 130provided by MGI
    Primary source
    MGI:MGI:1891717
    See related
    Ensembl:ENSMUSG00000020376 AllianceGenome:MGI:1891717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GP; G1rp; G1RZFP; GOLIATH; 2510042A13Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in programmed cell death. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; male reproductive system; retina; and urinary system. Orthologous to human RNF130 (ring finger protein 130). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.6), whole brain E14.5 (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf130 in Genome Data Viewer
    Location:
    11 B1.3; 11 30.16 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49916158..50016546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50025331..50125719)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5221 Neighboring gene mitogen-activated protein kinase 9 Neighboring gene predicted gene, 53699 Neighboring gene RasGEF domain family, member 1C Neighboring gene microRNA 340 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene TBC1 domain family, member 9B Neighboring gene predicted gene, 53700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis. Hao S, et al. EMBO Rep, 2023 Apr 5. PMID 36862324, Free PMC Article
    2. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Clifford BL, et al. Circ Res, 2023 Mar 31. PMID 36876496, Free PMC Article
    3. Cloning of murine G1RP, a novel gene related to Drosophila melanogaster g1. Baker SJ, et al. Gene, 2000 May 2. PMID 10806348
    4. RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination. Zhang J, et al. Int Immunopharmacol, 2023 Apr. PMID 36893517
    5. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination.
      Title: RNF130 protects against pulmonary fibrosis through suppressing aerobic glycolysis by mediating c-myc ubiquitination.
    2. Goliath induces inflammation in obese mice by linking fatty acid beta-oxidation to glycolysis.
      Title: Goliath induces inflammation in obese mice by linking fatty acid β-oxidation to glycolysis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • 2510042A13Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF130
    Names
    RING-type E3 ubiquitin transferase RNF130
    g1-related zinc finger protein
    goliath homolog
    NP_001277678.1
    NP_001277679.1
    NP_067515.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290749.1 → NP_001277678.1  E3 ubiquitin-protein ligase RNF130 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AI852677, AL645913, BC048901
      Consensus CDS
      CCDS78937.1
      UniProtKB/TrEMBL
      Q5SVR5
      Related
      ENSMUSP00000056345.8, ENSMUST00000054684.14
      Conserved Domains (3) summary
      COG5243
      Location:197 → 306
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

    2. NM_001290750.1 → NP_001277679.1  E3 ubiquitin-protein ligase RNF130 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (3) is the same length but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL627187, AL645913, BC048901, CB246244
      Consensus CDS
      CCDS88150.1
      UniProtKB/TrEMBL
      A0A571BES6
      Related
      ENSMUSP00000158797.2, ENSMUST00000238748.2
      Conserved Domains (3) summary
      COG5243
      Location:197 → 306
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

    3. NM_021540.4 → NP_067515.2  E3 ubiquitin-protein ligase RNF130 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AI852677, AL645913, BC048901
      Consensus CDS
      CCDS24626.1
      UniProtKB/Swiss-Prot
      Q80VL7, Q8VEM1, Q9QZQ6
      Related
      ENSMUSP00000099837.5, ENSMUST00000102776.5
      Conserved Domains (3) summary
      COG5243
      Location:197 → 306
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd02122
      Location:40 → 179
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16803
      Location:262 → 310
      RING-H2_RNF130; RING finger, H2 subclass, found in RING finger protein 130 (RNF130) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49916158..50016546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEM1.1 GenPept UniProtKB/Swiss-Prot:Q8VEM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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