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    Ifi207 interferon activated gene 207 [ Mus musculus (house mouse) ]

    Gene ID: 226691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifi207provided by MGI
    Official Full Name
    interferon activated gene 207provided by MGI
    Primary source
    MGI:MGI:2138302
    See related
    Ensembl:ENSMUSG00000073490 AllianceGenome:MGI:2138302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    pyhinA; Pyhin-A
    Summary
    Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of innate immune response. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 13.2), subcutaneous fat pad adult (RPKM 6.7) and 17 other tissues See more
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    Genomic context

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    See Ifi207 in Genome Data Viewer
    Location:
    1 H3; 1 80.61 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173550993..173569394, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173723424..173741831, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene pyrin and HIN domain family, member 1 pseudogene Neighboring gene predicted gene 7871 Neighboring gene interferon activated gene 204 Neighboring gene interferon activated gene 203, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:175731887-175732188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. Choubey D, et al. J Biol Chem, 1989 Oct 15. PMID 2477366
    2. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway. Moran EA, et al. mBio, 2024 Jul 17. PMID 38860764, Free PMC Article
    3. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
    4. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.
      Title: IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183622

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of AIM2 inflammasome complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC226691
    Names
    interferon-activatable protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204910.1 → NP_001191839.1  uncharacterized protein LOC226691

      Status: VALIDATED

      Source sequence(s)
      AC117682, AK054438, BE335648, BE634329, BX527645, CJ056316, CJ065456
      Consensus CDS
      CCDS56659.1
      UniProtKB/TrEMBL
      D3Z2E7, E9Q3L4
      Related
      ENSMUSP00000048129.8, ENSMUST00000042610.15
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; Pyrin: a protein-protein interaction domain
      pfam02760
      Location:788 → 954
      HIN; HIN-200/IF120x domain
      pfam06752
      Location:608 → 724
      E_Pc_C; Enhancer of Polycomb C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173550993..173569394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238800.4 → XP_011237102.1  uncharacterized protein LOC226691 isoform X6

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:574 → 766
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:785 → 951
      HIN; HIN-200/IF120x domain

    2. XM_011238799.4 → XP_011237101.1  uncharacterized protein LOC226691 isoform X5

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:574 → 813
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:799 → 965
      HIN; HIN-200/IF120x domain

    3. XM_036164142.1 → XP_036020035.1  uncharacterized protein LOC226691 isoform X4

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:574 → 827
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:813 → 979
      HIN; HIN-200/IF120x domain

    4. XM_011238798.4 → XP_011237100.1  uncharacterized protein LOC226691 isoform X2

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:572 → 853
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:839 → 1005
      HIN; HIN-200/IF120x domain

    5. XM_006496794.5 → XP_006496857.1  uncharacterized protein LOC226691 isoform X3

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:561 → 842
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:828 → 994
      HIN; HIN-200/IF120x domain

    6. XM_011238797.4 → XP_011237099.1  uncharacterized protein LOC226691 isoform X1

      UniProtKB/TrEMBL
      D3Z2E7
      Conserved Domains (3) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam05109
      Location:574 → 855
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02760
      Location:841 → 1007
      HIN; HIN-200/IF120x domain
    Nucleotide Protein Strain
    Heading Accession and Version

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