Klhl38 kelch-like 38 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klhl38provided by MGI
Official Full Name: kelch-like 38provided by MGI
Primary source: MGI:MGI:3045310
See related: Ensembl:ENSMUSG00000022357 AllianceGenome:MGI:3045310
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8230402K04Rik
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL38 (kelch like family member 38). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 7.9), mammary gland adult (RPKM 1.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D1; 15 24.62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (58176076..58187623, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (58314573..58324169, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation.
Title: KLHL38 facilitates staurosporine-induced apoptosis in HL-1 cells via myocardin degradation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kelch-like protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177755.3 → NP_808423.1 kelch-like protein 38

See identical proteins and their annotated locations for NP_808423.1

Status: PROVISIONAL

Source sequence(s)

AK033353

Consensus CDS

CCDS27492.1

UniProtKB/Swiss-Prot

Q8BSF5

Related

ENSMUSP00000022985.2, ENSMUST00000022985.2

Conserved Domains (7) summary

smart00612
Location:480 → 521

Kelch; Kelch domain

PHA03098
Location:48 → 560

PHA03098; kelch-like protein; Provisional

sd00038
Location:373 → 417

Kelch; KELCH repeat [structural motif]

pfam00651
Location:24 → 128

BTB; BTB/POZ domain

pfam01344
Location:510 → 560

Kelch_1; Kelch motif

pfam07707
Location:136 → 237

BACK; BTB And C-terminal Kelch

pfam13964
Location:281 → 321

Kelch_6; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

58176076..58187623 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159434.1 → XP_036015327.1 kelch-like protein 38 isoform X1

Conserved Domains (4) summary

PHA03098
Location:48 → 438

PHA03098; kelch-like protein; Provisional

sd00038
Location:322 → 370

Kelch; KELCH repeat [structural motif]

cd18476
Location:131 → 229

BACK_KLHL38; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38)

cl38908
Location:11 → 139

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily