Bsx brain specific homeobox [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bsxprovided by MGI
Official Full Name: brain specific homeoboxprovided by MGI
Primary source: MGI:MGI:2669849
See related: Ensembl:ENSMUSG00000054360 AllianceGenome:MGI:2669849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bsx1a; Bsx1b
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within eating behavior; locomotory behavior; and mammary gland involution. Located in nucleus. Part of transcription regulator complex. Is expressed in brain; metanephros; and renal vasculature. Orthologous to human BSX (brain specific homeobox). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 21.65 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (40782994..40790258)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (40874127..40878962)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Agouti related peptide is a common orexigenic target gene of glucocorticoid receptor and Bsx in the mouse hypothalamus.
Title: Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance.
Bsx and TTF-1 are transcriptional factors of NPY and AgRP in the arcuate nucleus[review]
Title: Role of homeobox genes in the hypothalamic development and energy balance.
binding of REST to neuron restrictive silencer element suppresses transcriptional activator Sp1-mediated activation of bsx in non-neuronal cells
Title: REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation.
Data demonstrate that BSX1A is a DNA binding protein and a transcriptional activator, and that BSX1A and BSX1B localize in the nuclei and cytoplasm, respectively.
Title: Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b.
Might be considered an important molecular marker for early embryonic stages of epiphysis development.
Title: Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus.
These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands.
Title: A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammary gland involution	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in stem cell population maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: brain-specific homeobox protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178245.3 → NP_839976.1 brain-specific homeobox protein homolog

See identical proteins and their annotated locations for NP_839976.1

Status: PROVISIONAL

Source sequence(s)

AC158355

Consensus CDS

CCDS23084.1

UniProtKB/Swiss-Prot

Q3SXB1, Q810B3

Related

ENSMUSP00000068057.4, ENSMUST00000067375.5

Conserved Domains (1) summary

pfam00046
Location:114 → 167

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

40782994..40790258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154982.1 → XP_036010875.1 brain-specific homeobox protein homolog isoform X1

UniProtKB/Swiss-Prot

Q3SXB1, Q810B3

Conserved Domains (1) summary

pfam00046
Location:114 → 167

Homeobox; Homeobox domain
XM_006510306.1 → XP_006510369.1 brain-specific homeobox protein homolog isoform X2

Conserved Domains (1) summary

pfam00046
Location:35 → 88

Homeobox; Homeobox domain