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    RSC4 Rsc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSC4
    Official Full Name
    Rsc4p
    Primary source
    SGD:S000001716
    Locus tag
    YKR008W
    See related
    AllianceGenome:SGD:S000001716; FungiDB:YKR008W; VEuPathDB:YKR008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysine-acetylated histone binding activity. Involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Part of RSC-type complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSC4 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (452201..454078)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL13 Neighboring gene Meh1p Neighboring gene bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of RSC58, which encodes a component of a yeast chromatin remodeling complex, and interacts with the transcription factor Swi6. Taneda T, et al. Mol Genet Genomics, 2004 May. PMID 15034784
    2. Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. VanDemark AP, et al. Mol Cell, 2007 Sep 7. PMID 17803945, Free PMC Article
    3. The yeast prefoldin-like URI-orthologue Bud27 associates with the RSC nucleosome remodeler and modulates transcription. Mirón-García MC, et al. Nucleic Acids Res, 2014 Sep. PMID 25081216, Free PMC Article
    4. BAF180 promotes cohesion and prevents genome instability and aneuploidy. Brownlee PM, et al. Cell Rep, 2014 Mar 27. PMID 24613357, Free PMC Article
    5. Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation. Choi JK, et al. Mol Cell Biol, 2008 Dec. PMID 18809572, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. vital and yet redundant functions of histone H3 and Rsc4p acetylation in maintaining cell viability
      Title: Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation.
    2. Rsc4 bears essential tandem bromodomains that rely on H3 Lys14 acetylation to assist RSC complex for gene activation
      Title: Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rsc4p
    NP_012933.4
    • Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      452201..454078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179798.4 → NP_012933.4  TPA: Rsc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012933.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX74, Q02206, Q6B1F7
      UniProtKB/TrEMBL
      B3LR92, C7GQG0, C8ZCH4, N1P0F9
      Conserved Domains (1) summary
      COG5076
      Location:40 → 423
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02206.2

    Gene LinkOut

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