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    RPL15A ribosomal 60S subunit protein L15A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPL15A
    Official Full Name
    ribosomal 60S subunit protein L15A
    Primary source
    SGD:S000004019
    Locus tag
    YLR029C
    See related
    AllianceGenome:SGD:S000004019; FungiDB:YLR029C; VEuPathDB:YLR029C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL10A
    Summary
    Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 12. Orthologous to human RPL15 (ribosomal protein L15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPL15A in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (201976..202590, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The oxidative stress-sensitive yap1 null strain of Saccharomyces cerevisiae becomes resistant due to increased carotenoid levels upon the introduction of the Chlamydomonas reinhardtii cDNA, coding for the 60S ribosomal protein L10a. Méndez-Alvarez S, et al. Biochem Biophys Res Commun, 2000 Jan 27. PMID 10673398
    2. Functional characterization of ribosomal protein L15 from Saccharomyces cerevisiae. Simoff I, et al. Curr Genet, 2009 Apr. PMID 19184027
    3. A distinct nuclear import pathway used by ribosomal proteins. Rout MP, et al. Cell, 1997 May 30. PMID 9182759
    4. Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. Lee JC, et al. J Biol Chem, 1983 Jan 25. PMID 6337137
    5. Analysis of the interplay of protein biogenesis factors at the ribosome exit site reveals new role for NAC. Nyathi Y, et al. J Cell Biol, 2015 Jul 20. PMID 26195668, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L15A
    NP_013129.1
    • Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      201976..202590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181916.1 → NP_013129.1  TPA: ribosomal 60S subunit protein L15A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013129.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY31, P05748
      UniProtKB/TrEMBL
      A7A0T5, B3LT02, C7GXH5, C8ZD01, G2WIM3, N1P248
      Conserved Domains (1) summary
      pfam00827
      Location:2 → 189
      Ribosomal_L15e; Ribosomal L15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05748.3

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