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    PRP39 Prp39p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP39
    Official Full Name
    Prp39p
    Primary source
    SGD:S000004509
    Locus tag
    YML046W
    See related
    AllianceGenome:SGD:S000004509; FungiDB:YML046W; VEuPathDB:YML046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to pre-mRNA 5'-splice site binding activity. Involved in mRNA 5'-splice site recognition. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Orthologous to human PRPF39 (pre-mRNA processing factor 39). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP39 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (181474..183363)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Gsf2p Neighboring gene pheromone-regulated K(+) transporter PRM6 Neighboring gene tRNA-Gly Neighboring gene gag protein Neighboring gene gag-pol fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p. Lockhart SR, et al. Mol Cell Biol, 1994 Jun. PMID 8196608, Free PMC Article
    2. Yeast pre-mRNA splicing requires a pair of U1 snRNP-associated tetratricopeptide repeat proteins. McLean MR, et al. Mol Cell Biol, 1998 Jan. PMID 9418882, Free PMC Article
    3. The identification and characterization of a novel splicing protein, Isy1p, of Saccharomyces cerevisiae. Dix I, et al. RNA, 1999 Mar. PMID 10094305, Free PMC Article
    4. The undertranslated transcriptome reveals widespread translational silencing by alternative 5' transcript leaders. Law GL, et al. Genome Biol, 2005. PMID 16420678, Free PMC Article
    5. An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. Price AM, et al. RNA, 2014 Jan. PMID 24231520, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to pre-mRNA 5'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to pre-mRNA 5'-splice site binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 5'-splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 5'-splice site recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Prp39p
    NP_013667.1
    • U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      181474..183363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182403.1 → NP_013667.1  TPA: Prp39p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013667.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZC9, E9P8Z1, P39682
      UniProtKB/TrEMBL
      C7GS62, C8ZEG3, G2WK11, N1P698
      Conserved Domains (1) summary
      COG5107
      Location:121 → 217
      RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39682.1

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