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    AIM32 Aim32p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AIM32
    Official Full Name
    Aim32p
    Primary source
    SGD:S000004514
    Locus tag
    YML050W
    See related
    AllianceGenome:SGD:S000004514; FungiDB:YML050W; VEuPathDB:YML050W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within cell redox homeostasis and protein-containing complex assembly. Located in mitochondrial intermembrane space and mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AIM32 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (173139..174074)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sur7p Neighboring gene transcription regulator GAL80 Neighboring gene U2 snRNP complex subunit RSE1 Neighboring gene Gsf2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Apd1 and Aim32 Are Prototypes of Bishistidinyl-Coordinated Non-Rieske [2Fe-2S] Proteins. Stegmaier K, et al. J Am Chem Soc, 2019 Apr 10. PMID 30879301
    2. The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth. Lalève A, et al. Redox Biol, 2016 Apr. PMID 26629948, Free PMC Article
    3. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control. Zhang D, et al. J Biol Chem, 2021 Oct. PMID 34461091, Free PMC Article
    4. An ER surface retrieval pathway safeguards the import of mitochondrial membrane proteins in yeast. Hansen KG, et al. Science, 2018 Sep 14. PMID 30213914
    5. The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. Brown CR, et al. J Biol Chem, 2010 Jul 23. PMID 20457600, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control.
      Title: Aim32 is a dual-localized 2Fe-2S mitochondrial protein that functions in redox quality control.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Aim32p
    NP_013662.1
    • 2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      173139..174074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182408.1 → NP_013662.1  TPA: Aim32p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013662.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZM17, B3LLK7, B5VP80, C7GS66, C8ZEF8, D6VZC5, Q04689
      UniProtKB/TrEMBL
      G2WK07, N1P692
      Conserved Domains (1) summary
      pfam06999
      Location:60 → 306
      Suc_Fer-like; Sucrase/ferredoxin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04689.1

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