Fbxo3 F-box protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo3provided by MGI
Official Full Name: F-box protein 3provided by MGI
Primary source: MGI:MGI:1929084
See related: Ensembl:ENSMUSG00000027180 AllianceGenome:MGI:1929084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fba; 1200002G09Rik; 1700026K02Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO3 (F-box protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 12.3), liver E14 (RPKM 12.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E2; 2 54.49 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (103858144..103893582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (104027799..104063237)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
Title: FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis.
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
Title: E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury.
AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity.
Title: FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI046358 (e-PCR)
- UniSTS:158993

01.MMHAP54FLA1.seq (e-PCR)
- UniSTS:122658

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 3

Names: F-box protein FBA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355504.1 → NP_001342433.1 F-box only protein 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' end compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BX640578

Conserved Domains (2) summary

smart00860
Location:91 → 219

SMI1_KNR4; SMI1 / KNR4 family

cl01119
Location:249 → 374

DUF525; ApaG domain
NM_001355505.1 → NP_001342434.1 F-box only protein 3 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BX640578

Related

ENSMUSP00000106765.2, ENSMUST00000111135.8

Conserved Domains (3) summary

smart00860
Location:121 → 249

SMI1_KNR4; SMI1 / KNR4 family

pfam12937
Location:13 → 57

F-box-like; F-box-like

cl01119
Location:279 → 404

DUF525; ApaG domain
NM_001355506.1 → NP_001342435.1 F-box only protein 3 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' end and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

BX640578

Conserved Domains (2) summary

smart00860
Location:91 → 219

SMI1_KNR4; SMI1 / KNR4 family

cl01119
Location:249 → 374

DUF525; ApaG domain
NM_001355507.1 → NP_001342436.1 F-box only protein 3 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK085686, BX640578

Consensus CDS

CCDS89529.1

UniProtKB/TrEMBL

A2BHN6

Related

ENSMUSP00000106766.2, ENSMUST00000111136.8

Conserved Domains (3) summary

smart00860
Location:121 → 249

SMI1_KNR4; SMI1 / KNR4 family

pfam12937
Location:13 → 57

F-box-like

cl01119
Location:279 → 358

DUF525; ApaG domain
NM_020593.2 → NP_065618.1 F-box only protein 3 isoform 2

See identical proteins and their annotated locations for NP_065618.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AF233226, AK006392, BY105498

Consensus CDS

CCDS16485.1

UniProtKB/Swiss-Prot

Q9DC63

UniProtKB/TrEMBL

Q9CVV6

Related

ENSMUSP00000099625.4, ENSMUST00000102565.4

Conserved Domains (3) summary

pfam09346
Location:121 → 249

SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)

pfam12937
Location:13 → 57

F-box-like; F-box-like

cl01119
Location:279 → 404

DUF525; Protein of unknown function (DUF525)
NM_212433.1 → NP_997598.1 F-box only protein 3 isoform 1

See identical proteins and their annotated locations for NP_997598.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK029594, AK049870, BB470024, BE980708, BY105498

Consensus CDS

CCDS16484.1

UniProtKB/Swiss-Prot

A2BHN5, A2BHN7, Q3TKB0, Q3U9C1, Q8C7I0, Q8CEJ0, Q91VI9, Q9D2J5, Q9DC63, Q9JIE4

Related

ENSMUSP00000028603.4, ENSMUST00000028603.10

Conserved Domains (3) summary

pfam09346
Location:121 → 249

SMI1_KNR4; SMI1 / KNR4 family (SUKH-1)

pfam12937
Location:13 → 57

F-box-like; F-box-like

cl01119
Location:279 → 404

DUF525; Protein of unknown function (DUF525)

RNA

NR_149726.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate internal exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK150097, BX640578

Related

ENSMUST00000143799.2