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    Hs3st6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 328779, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st6provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 6provided by MGI
    Primary source
    MGI:MGI:3580487
    See related
    Ensembl:ENSMUSG00000039628 AllianceGenome:MGI:3580487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3-OST-6
    Summary
    Enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within blastocyst hatching. Predicted to be located in Golgi membrane. Is expressed in alimentary system; early conceptus; integumental system; lung; and nervous system. Human ortholog(s) of this gene implicated in hereditary angioedema. Orthologous to human HS3ST6 (heparan sulfate-glucosamine 3-sulfotransferase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 10.9), genital fat pad adult (RPKM 9.3) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hs3st6 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24971565..24977664)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24752988..24758690)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene ribosomal protein L3-like Neighboring gene methionine sulfoxide reductase B1 Neighboring gene meiosis specific with OB domains Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. Xu D, et al. Biochem J, 2005 Jan 15. PMID 15303968, Free PMC Article
    2. WT1 controls antagonistic FGF and BMP-pSMAD pathways in early renal progenitors. Motamedi FJ, et al. Nat Commun, 2014 Jul 17. PMID 25031030
    3. Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Patel VN, et al. Matrix Biol, 2021 Sep. PMID 34653670, Free PMC Article
    4. Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Patel VN, et al. Nat Commun, 2024 Aug 31. PMID 39217171, Free PMC Article
    5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 6
    Names
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6
    NP_001012402.1
    NP_001344269.1
    NP_001344271.1
    XP_006524490.1
    XP_030105708.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012402.2 → NP_001012402.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 1

      See identical proteins and their annotated locations for NP_001012402.1

      Status: VALIDATED

      Source sequence(s)
      AK146974, AY574375
      Consensus CDS
      CCDS28496.1
      UniProtKB/Swiss-Prot
      Q5GFD5
      UniProtKB/TrEMBL
      A2RTI7, B7ZNT8
      Related
      ENSMUSP00000040919.7, ENSMUST00000044922.8
      Conserved Domains (1) summary
      pfam00685
      Location:91 → 326
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001357340.1 → NP_001344269.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK146974, AY574375
      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30 → 186
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_001357342.1 → NP_001344271.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154566, AY574375
      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30 → 186
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24971565..24977664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249848.2 → XP_030105708.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:51 → 207
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_006524427.5 → XP_006524490.1  heparan sulfate glucosamine 3-O-sulfotransferase 6 isoform X2

      See identical proteins and their annotated locations for XP_006524490.1

      UniProtKB/TrEMBL
      Q3UIC7
      Conserved Domains (1) summary
      pfam00685
      Location:30 → 186
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GFD5.1 GenPept UniProtKB/Swiss-Prot:Q5GFD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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