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    B3galt1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 26877, updated on 27-Nov-2024

    Summary

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    Official Symbol
    B3galt1provided by MGI
    Official Full Name
    UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:1349403
    See related
    Ensembl:ENSMUSG00000034780 AllianceGenome:MGI:1349403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    beta3Gal-T1
    Summary
    Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Located in Golgi membrane. Is expressed in nervous system. Orthologous to human B3GALT1 (beta-1,3-galactosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.5), frontal lobe adult (RPKM 4.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See B3galt1 in Genome Data Viewer
    Location:
    2 C1.3; 2 39.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (67395528..67953226)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (67565689..68122882)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23328 Neighboring gene xin actin-binding repeat containing 2 Neighboring gene predicted gene 13601 Neighboring gene VISTA enhancer mm1717 Neighboring gene microRNA 7224 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene microRNA 6335 Neighboring gene predicted gene, 54157 Neighboring gene STARR-seq mESC enhancer starr_04706 Neighboring gene actin-like 6A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04707 Neighboring gene STARR-seq mESC enhancer starr_04708 Neighboring gene STARR-seq mESC enhancer starr_04709 Neighboring gene STARR-seq mESC enhancer starr_04712 Neighboring gene serine/threonine kinase 39 Neighboring gene predicted gene, 54158 Neighboring gene predicted gene 13596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional assignment of motifs conserved in beta 1,3-glycosyltransferases. Malissard M, et al. Eur J Biochem, 2002 Jan. PMID 11784317
    2. Developmental regulation of beta-1,3-galactosyltransferase-1 gene expression in mouse brain. Zhu D, et al. FEBS Lett, 2003 Mar 13. PMID 12633872
    3. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
    4. Proteomics characterization of abundant Golgi membrane proteins. Bell AW, et al. J Biol Chem, 2001 Feb 16. PMID 11042173
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in galactosylceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactosylceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-1,3-galactosyltransferase 1
    Names
    UDP-galactose:beta-N-acetylglucosamine beta1, 3-galactosyltransferase 1
    beta-1,3-GalTase 1
    NP_001366253.1
    NP_001366254.1
    NP_001366255.1
    NP_001366256.1
    NP_001366257.1
    NP_001366258.1
    NP_001399338.1
    NP_001399339.1
    NP_064679.2
    XP_036018121.1
    XP_036018122.1
    XP_036018123.1
    XP_036018124.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379324.1 → NP_001366253.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 and 11 all encode the same protein.
      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    2. NM_001379325.1 → NP_001366254.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    3. NM_001379326.1 → NP_001366255.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    4. NM_001379327.1 → NP_001366256.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    5. NM_001379328.1 → NP_001366257.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    6. NM_001379329.1 → NP_001366258.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    7. NM_001412409.1 → NP_001399338.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3

    8. NM_001412410.1 → NP_001399339.1  beta-1,3-galactosyltransferase 1

      Status: VALIDATED

      Source sequence(s)
      AL845519, AL928598, AL929125, AL929411, BX936296
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3

    9. NM_020283.4 → NP_064679.2  beta-1,3-galactosyltransferase 1

      See identical proteins and their annotated locations for NP_064679.2

      Status: VALIDATED

      Source sequence(s)
      AK035215, BC094660, BX936296
      Consensus CDS
      CCDS16083.1
      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Related
      ENSMUSP00000041343.4, ENSMUST00000042456.4
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    RNA

    1. NR_178190.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929125, AL929411

    2. NR_178191.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929125, AL929411

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      67395528..67953226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162229.1 → XP_036018122.1  beta-1,3-galactosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    2. XM_036162230.1 → XP_036018123.1  beta-1,3-galactosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase

    3. XM_036162231.1 → XP_036018124.1  beta-1,3-galactosyltransferase 1 isoform X2

    4. XM_036162228.1 → XP_036018121.1  beta-1,3-galactosyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54904, Q91V52
      UniProtKB/TrEMBL
      Q505A3
      Conserved Domains (1) summary
      pfam01762
      Location:92 → 279
      Galactosyl_T; Galactosyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54904.2 GenPept UniProtKB/Swiss-Prot:O54904

    Gene LinkOut

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