Ctsk cathepsin K [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctskprovided by MGI
Official Full Name: cathepsin Kprovided by MGI
Primary source: MGI:MGI:107823
See related: Ensembl:ENSMUSG00000028111 AllianceGenome:MGI:107823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: catK; Ms10q; MMS10-Q
Summary: This gene encodes a member of the cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]
Expression: Biased expression in bladder adult (RPKM 27.4), limb E14.5 (RPKM 13.7) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95406521..95416698)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95499210..95509387)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial-mesenchymal trophic unit activation in asthma.
Title: Airway epithelial overexpressed cathepsin K induces airway remodelling through epithelial-mesenchymal trophic unit activation in asthma.
Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl3 model.
Title: Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl(3) model.
[Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice].
Title: [Deficiency of cathepsin K improves ischemic angiogenesis in high-fat diet fed mice].
Altering osteoclast numbers using CTSK models in utero affects mice offspring craniofacial morphology.
Title: Altering osteoclast numbers using CTSK models in utero affects mice offspring craniofacial morphology.
Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Title: Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis.
Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice.
Title: Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice.
Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress.
Title: Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress.
Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination.
Title: Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination.
The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
Title: The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K.
[Activation of mir-30a-wnt/beta-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells].
Title: [Activation of mir-30a-wnt/β-catenin signaling pathway upregulates cathepsin K expression to promote cementogenic differentiation of periodontal ligament stem cells].

Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (9)
Targeted (11) 1 citation

General gene information

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Markers

PMC24840P1 (e-PCR)
- UniSTS:272275

Ctsk (e-PCR), detects polymorphism
- UniSTS:498341

AI323530 (e-PCR)
- UniSTS:178872

UniSTS:496617 (e-PCR)
- UniSTS:496617

Ctsk (e-PCR), detects polymorphism
- UniSTS:496617

Ctsk (e-PCR), detects polymorphism
- UniSTS:498425

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables fibronectin binding	IEA Inferred from Electronic Annotation more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables proteoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone resorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to zinc ion starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within collagen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collagen catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in collagen catabolic process	ISO Inferred from Sequence Orthology more info
involved_in intramembranous ossification	IEA Inferred from Electronic Annotation more info
involved_in mononuclear cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cathepsin K

Names: Cat K

NP_031828.2

EC 3.4.22.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007802.4 → NP_031828.2 cathepsin K preproprotein

See identical proteins and their annotated locations for NP_031828.2

Status: REVIEWED

Source sequence(s)

AC092203, AK132648, D18958

Consensus CDS

CCDS17615.1

UniProtKB/Swiss-Prot

O88718, P55097

UniProtKB/TrEMBL

Q545T0

Related

ENSMUSP00000015664.4, ENSMUST00000015664.5

Conserved Domains (2) summary

smart00848
Location:26 → 85

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

cd02248
Location:116 → 327

Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...