Sst somatostatin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sstprovided by MGI
Official Full Name: somatostatinprovided by MGI
Primary source: MGI:MGI:98326
See related: Ensembl:ENSMUSG00000004366 AllianceGenome:MGI:98326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SS; SOM; SRIF; Smst
Summary: Enables receptor ligand activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and somatostatin signaling pathway. Acts upstream of or within regulation of cell migration. Located in extracellular space. Is active in GABA-ergic synapse and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human SST (somatostatin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in stomach adult (RPKM 471.4), cortex adult (RPKM 146.8) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B1; 16 15.0 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (23708327..23710041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (23889573..23891342, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Somatostatin Interneurons Recruit Pre- and Postsynaptic GABAB Receptors in the Adult Mouse Dentate Gyrus.
Title: Somatostatin Interneurons Recruit Pre- and Postsynaptic GABA(B) Receptors in the Adult Mouse Dentate Gyrus.
Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.
Title: Inhibition of somatostatin enhances the long-term metabolic outcomes of sleeve gastrectomy in mice.
Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
Title: Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain.
Activated somatostatin interneurons orchestrate memory microcircuits.
Title: Activated somatostatin interneurons orchestrate memory microcircuits.
Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.
Title: Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.
Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
Title: Beta cell primary cilia mediate somatostatin responsiveness via SSTR3.
Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Title: Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Fear memory recall involves hippocampal somatostatin interneurons.
Title: Fear memory recall involves hippocampal somatostatin interneurons.
Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
Title: Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons.
Phase- and state-dependent modulation of breathing pattern by preBotzinger complex somatostatin expressing neurons.
Title: Phase- and state-dependent modulation of breathing pattern by preBötzinger complex somatostatin expressing neurons.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (14) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SST-112F (e-PCR)
- UniSTS:25600

Smst (e-PCR), detects polymorphism
- UniSTS:158760

Smst (e-PCR), detects polymorphism
- UniSTS:144450

Smst (e-PCR), detects polymorphism
- UniSTS:144451

PMC123023P2 (e-PCR)
- UniSTS:270423

Sst (e-PCR), detects polymorphism
- UniSTS:507246

PMC24644P1 (e-PCR)
- UniSTS:272267

X51468 (e-PCR)
- UniSTS:180877

UniSTS:256695 (e-PCR)
- UniSTS:256695

Sst (e-PCR), detects polymorphism
- UniSTS:256695

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in hyperosmotic response	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in response to amino acid	IEA Inferred from Electronic Annotation more info
involved_in response to steroid hormone	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in somatostatin signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: somatostatin

Names: preprosomatostatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417475.1 → NP_001404404.1 somatostatin precursor

Status: VALIDATED

Source sequence(s)

AC127241

UniProtKB/Swiss-Prot

P01167, P60041

UniProtKB/TrEMBL

Q545V6
NM_009215.2 → NP_033241.1 somatostatin precursor

See identical proteins and their annotated locations for NP_033241.1

Status: VALIDATED

Source sequence(s)

AC127241

Consensus CDS

CCDS28080.1

UniProtKB/Swiss-Prot

P01167, P60041

UniProtKB/TrEMBL

Q545V6

Related

ENSMUSP00000004480.4, ENSMUST00000004480.5

Conserved Domains (1) summary

pfam03002
Location:99 → 116

Somatostatin; Somatostatin/Cortistatin family