Dst dystonin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dstprovided by MGI
Official Full Name: dystoninprovided by MGI
Primary source: MGI:MGI:104627
See related: Ensembl:ENSMUSG00000026131 AllianceGenome:MGI:104627
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ah; dt; Bpag; BP230; Bpag1; Macf2; nmf203; nmf339; BPAG1-n; athetoid; mKIAA0728; 2310001O04Rik; A830042E19Rik
Summary: Enables protein homodimerization activity. Involved in cytoskeleton organization and retrograde axonal transport. Acts upstream of or within axonogenesis. Located in several cellular components, including cytoskeleton; endoplasmic reticulum; and sarcomere. Is active in type III intermediate filament. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina nuclear layer. Used to study hereditary sensory and autonomic neuropathy type 6 and hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex and hereditary sensory and autonomic neuropathy type 6. Orthologous to human DST (dystonin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.8), bladder adult (RPKM 7.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 12.91 cM

Exon count:: 113

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (33946969..34347743)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (33907888..34308662)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The DST gene in neurobiology.
Title: The DST gene in neurobiology.
Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues.
Title: Roles of dystonin isoforms in the maintenance of neural, muscle, and cutaneous tissues.
Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum.
Title: Dystonin modifiers of junctional epidermolysis bullosa and models of epidermolysis bullosa simplex without dystonia musculorum.
Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.
Title: Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy.
Autoantibodies to BPAG1e Trigger Experimental Bullous Pemphigoid in Mice.
Title: Autoantibodies to BPAG1e Trigger Experimental Bullous Pemphigoid in Mice.
Dystonin loss-of-function leads to impaired autophagosome-endolysosome pathway dynamics.
Title: Dystonin loss-of-function leads to impaired autophagosome-endolysosome pathway dynamics.
Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.
Title: Diverse dystonin gene mutations cause distinct patterns of Dst isoform deficiency and phenotypic heterogeneity in Dystonia musculorum mice.
FLG and DST support melanoma cell growth in vitro and in vivo. Growth effects of JUP were only evident in vivo, and may be mediated, in part, by enhancing angiogenesis. In addition, growth-promoting effects of FLG and DST in vitro suggest that these genes may also support melanoma cell proliferation through angiogenesis-independent pathways.
Title: The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.
Our finding suggests that DST alteration may involve in the mechanism of diabetic dementia
Title: Dystonin/BPAG1 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.
Microtubule instability is not central to initiation of dystonia musculorum (Dstdt) pathogenesis, though it may contribute to disease severity. Maintenance of microtubule stability in Dstdt-Tg4 dorsal root ganglia could be attributed to an upregulation in Dst-A3 expression as a compensation for the absence of Dst-A1 and -A2 in Dstdt-Tg4 sensory neurons.
Title: Dystonin-A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (6)
Chemically induced (other) (1)
Endonuclease-mediated (19) 1 citation
Gene trapped (3) 1 citation
Spontaneous (16) 1 citation
Targeted (3) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF405229 (e-PCR)
- UniSTS:247835

ha3079 (e-PCR)
- UniSTS:515639

NoName (e-PCR)
- UniSTS:234101

AW554249 (e-PCR)
- UniSTS:178373

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in hemidesmosome assembly	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular transport	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde axonal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in H zone	IDA Inferred from Direct Assay more info	PubMed
located_in H zone	IEA Inferred from Electronic Annotation more info
is_active_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
is_active_in hemidesmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
located_in hemidesmosome	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISO Inferred from Sequence Orthology more info
located_in microtubule plus-end	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
is_active_in type III intermediate filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystonin

Names: BPA; dystonia musculorum protein; hemidesmosomal plaque protein; microtubule actin cross-linking factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276764.1 → NP_001263693.1 dystonin isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC123072, AC124386, AC127433

Consensus CDS

CCDS69874.1

UniProtKB/TrEMBL

S4R1P5

Related

ENSMUSP00000138308.2, ENSMUST00000183034.5

Conserved Domains (9) summary

smart00150
Location:786 → 877

SPEC; Spectrin repeats

cd00014
Location:214 → 316

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:7310 → 7372

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6488 → 6703

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3715 → 4529

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1950 → 1990

Plectin; Plectin repeat

pfam02187
Location:7388 → 7461

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam13499
Location:7311 → 7371

EF-hand_7; EF-hand domain pair

cl02488
Location:1371 → 1535

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_010081.3 → NP_034211.2 dystonin isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4, also known as e) has multiple differences in the coding region and UTRs compared to variant 1. This variant encodes isoform 4 (also known as e), which has distinct N- and C-termini and is significantly shorter than isoform 1.

Source sequence(s)

AC127433

Consensus CDS

CCDS69875.1

UniProtKB/Swiss-Prot

Q91ZU6

Related

ENSMUSP00000138376.4, ENSMUST00000183302.6

Conserved Domains (7) summary

smart00150
Location:282 → 373

SPEC; Spectrin repeats

smart00250
Location:2504 → 2541

PLEC; Plectin repeat

COG1196
Location:721 → 1477

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:375 → 563

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00681
Location:2467 → 2506

Plectin; Plectin repeat

pfam09728
Location:1399 → 1712

Taxilin; Myosin-like coiled-coil protein

cl02488
Location:867 → 1031

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_133833.4 → NP_598594.2 dystonin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3, also known as a) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks seven alternate in-frame exons in the coding region. The encoded isoform (3, also known as a) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC123072, AC124386, AC127433

Consensus CDS

CCDS35535.1

UniProtKB/TrEMBL

A0A087WSP0

Related

ENSMUSP00000095393.3, ENSMUST00000097786.10

Conserved Domains (8) summary

smart00150
Location:608 → 699

SPEC; Spectrin repeats

cd00014
Location:36 → 138

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:5009 → 5071

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4187 → 4402

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1480 → 2337

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam02187
Location:5087 → 5160

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam13499
Location:5010 → 5070

EF-hand_7; EF-hand domain pair

cl02488
Location:1193 → 1357

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_134448.4 → NP_604443.2 dystonin isoform 2

See identical proteins and their annotated locations for NP_604443.2

Status: VALIDATED

Description

Transcript Variant: This variant (2, also known as b) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. This variant also lacks two alternate in-frame exons in the coding region. The encoded isoform (2, also known as b) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC123072, AC124386, AC127433

Consensus CDS

CCDS35534.1

UniProtKB/Swiss-Prot

E9PXE5, E9QL23, Q1KP04, Q3I6J6, Q60824, Q60845, Q8K5D4, Q91ZU6, Q91ZU7, Q91ZU8, Q9WU50, S4R1U5

Related

ENSMUSP00000095392.3, ENSMUST00000097785.10

Conserved Domains (9) summary

smart00150
Location:608 → 699

SPEC; Spectrin repeats

cd00014
Location:36 → 138

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:7023 → 7085

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6201 → 6416

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3537 → 4351

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:1772 → 1812

Plectin; Plectin repeat

pfam02187
Location:7101 → 7174

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam13499
Location:7024 → 7084

EF-hand_7; EF-hand domain pair

cl02488
Location:1193 → 1357

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

33946969..34347743

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495666.4 → XP_006495729.1 dystonin isoform X3

Conserved Domains (12) summary

pfam05483
Location:1261 → 1451

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:786 → 877

SPEC; Spectrin repeats

COG1196
Location:4346 → 5241

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 432

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7311 → 7373

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6489 → 6704

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3662 → 4440

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1285 → 1723

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1951 → 1991

Plectin; Plectin repeat

pfam02187
Location:7388 → 7462

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1054 → 1120

SH3_10; SH3 domain

pfam18373
Location:1155 → 1232

Spectrin_like; Spectrin like domain
XM_006495690.4 → XP_006495753.1 dystonin isoform X34

Conserved Domains (12) summary

pfam05483
Location:1261 → 1451

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7386 → 7458

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:786 → 877

SPEC; Spectrin repeats

COG1196
Location:4346 → 5241

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 432

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7311 → 7373

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6489 → 6704

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3662 → 4440

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1285 → 1723

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1951 → 1991

Plectin; Plectin repeat

pfam17902
Location:1054 → 1120

SH3_10; SH3 domain

pfam18373
Location:1155 → 1232

Spectrin_like; Spectrin like domain
XM_006495691.4 → XP_006495754.1 dystonin isoform X33

Conserved Domains (12) summary

pfam05483
Location:1261 → 1451

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7277 → 7355

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:786 → 877

SPEC; Spectrin repeats

COG1196
Location:4346 → 5241

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 432

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7202 → 7264

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6380 → 6595

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3662 → 4440

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1285 → 1723

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1951 → 1991

Plectin; Plectin repeat

pfam17902
Location:1054 → 1120

SH3_10; SH3 domain

pfam18373
Location:1155 → 1232

Spectrin_like; Spectrin like domain
XM_036158508.1 → XP_036014401.1 dystonin isoform X23

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

smart00150
Location:786 → 877

SPEC; Spectrin repeats

COG1196
Location:2332 → 3227

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5297 → 5359

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4475 → 4690

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1659 → 2516

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1385 → 1811

CCDC158; Coiled-coil domain-containing protein 158

pfam02187
Location:5374 → 5448

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1054 → 1120

SH3_10; SH3 domain

pfam18373
Location:1155 → 1232

Spectrin_like; Spectrin like domain

cd21236
Location:201 → 325

CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins

cd21239
Location:330 → 433

CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
XM_006495682.3 → XP_006495745.1 dystonin isoform X24

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

pfam05483
Location:1261 → 1451

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:786 → 877

SPEC; Spectrin repeats

COG1196
Location:2332 → 3227

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 432

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5297 → 5359

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4475 → 4690

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1659 → 2516

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1372 → 1536

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:5374 → 5448

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1054 → 1120

SH3_10; SH3 domain

pfam18373
Location:1155 → 1232

Spectrin_like; Spectrin like domain
XM_017314621.2 → XP_017170110.1 dystonin isoform X1

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7400 → 7474

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314676.2 → XP_017170165.1 dystonin isoform X6

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7400 → 7474

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314651.2 → XP_017170140.1 dystonin isoform X4

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7398 → 7476

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314687.2 → XP_017170176.1 dystonin isoform X8

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7398 → 7476

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314635.2 → XP_017170124.1 dystonin isoform X2

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7400 → 7468

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_030246500.1 → XP_030102360.1 dystonin isoform X7

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7400 → 7468

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314665.2 → XP_017170154.1 dystonin isoform X5

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7398 → 7470

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314706.2 → XP_017170195.1 dystonin isoform X11

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7214 → 7276

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6392 → 6607

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7291 → 7365

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314722.2 → XP_017170211.1 dystonin isoform X14

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7214 → 7276

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6392 → 6607

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam02187
Location:7291 → 7365

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314794.2 → XP_017170283.1 dystonin isoform X22

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:2344 → 3239

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5309 → 5371

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4487 → 4702

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1671 → 2528

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1384 → 1548

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:5386 → 5460

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314811.2 → XP_017170300.1 dystonin isoform X25

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:2344 → 3239

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5200 → 5262

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4378 → 4593

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1671 → 2528

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1384 → 1548

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:5277 → 5351

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314689.2 → XP_017170178.1 dystonin isoform X9

Conserved Domains (12) summary

pfam05483
Location:1273 → 1463

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00243
Location:7398 → 7470

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:798 → 889

SPEC; Spectrin repeats

COG1196
Location:4358 → 5253

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:208 → 444

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7323 → 7385

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6501 → 6716

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3674 → 4452

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1297 → 1735

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1963 → 2003

Plectin; Plectin repeat

pfam17902
Location:1066 → 1132

SH3_10; SH3 domain

pfam18373
Location:1167 → 1244

Spectrin_like; Spectrin like domain
XM_017314716.3 → XP_017170205.1 dystonin isoform X13

Conserved Domains (12) summary

pfam05483
Location:1135 → 1325

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:660 → 751

SPEC; Spectrin repeats

COG1196
Location:4220 → 5115

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:70 → 306

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7185 → 7247

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6363 → 6578

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3536 → 4314

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1159 → 1597

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1825 → 1865

Plectin; Plectin repeat

pfam02187
Location:7262 → 7336

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:928 → 994

SH3_10; SH3 domain

pfam18373
Location:1029 → 1106

Spectrin_like; Spectrin like domain
XM_006495674.5 → XP_006495737.1 dystonin isoform X15

Conserved Domains (12) summary

pfam05483
Location:1123 → 1313

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:648 → 739

SPEC; Spectrin repeats

COG1196
Location:4208 → 5103

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:70 → 294

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7173 → 7235

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6351 → 6566

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3524 → 4302

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1147 → 1585

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1813 → 1853

Plectin; Plectin repeat

pfam02187
Location:7250 → 7324

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:916 → 982

SH3_10; SH3 domain

pfam18373
Location:1017 → 1094

Spectrin_like; Spectrin like domain
XM_017314712.3 → XP_017170201.1 dystonin isoform X12

Conserved Domains (12) summary

pfam05483
Location:1139 → 1329

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:664 → 755

SPEC; Spectrin repeats

COG1196
Location:4224 → 5119

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:74 → 310

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7189 → 7251

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6367 → 6582

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3540 → 4318

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1163 → 1601

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1829 → 1869

Plectin; Plectin repeat

pfam02187
Location:7266 → 7340

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:932 → 998

SH3_10; SH3 domain

pfam18373
Location:1033 → 1110

Spectrin_like; Spectrin like domain
XM_017314741.2 → XP_017170230.1 dystonin isoform X16

Conserved Domains (12) summary

pfam05483
Location:1095 → 1285

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:620 → 711

SPEC; Spectrin repeats

COG1196
Location:4180 → 5075

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 266

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7145 → 7207

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6323 → 6538

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3496 → 4274

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1119 → 1557

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1785 → 1825

Plectin; Plectin repeat

pfam02187
Location:7222 → 7296

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:888 → 954

SH3_10; SH3 domain

pfam18373
Location:989 → 1066

Spectrin_like; Spectrin like domain
XM_006495678.4 → XP_006495741.1 dystonin isoform X18

Conserved Domains (12) summary

pfam05483
Location:1083 → 1273

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:4168 → 5063

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 254

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7133 → 7195

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6311 → 6526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3484 → 4262

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1107 → 1545

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1773 → 1813

Plectin; Plectin repeat

pfam02187
Location:7210 → 7284

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain
XM_006495688.4 → XP_006495751.1 dystonin isoform X32

Conserved Domains (12) summary

pfam05483
Location:1083 → 1273

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:4168 → 5063

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 254

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7133 → 7195

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6311 → 6526

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3484 → 4262

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1107 → 1545

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1773 → 1813

Plectin; Plectin repeat

pfam02187
Location:7210 → 7284

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain
XM_017314848.2 → XP_017170337.1 dystonin isoform X31

Conserved Domains (12) summary

pfam05483
Location:1083 → 1273

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:4168 → 5063

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 254

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7024 → 7086

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6202 → 6417

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3484 → 4262

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1107 → 1545

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1773 → 1813

Plectin; Plectin repeat

pfam02187
Location:7101 → 7175

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain
XM_006495684.4 → XP_006495747.1 dystonin isoform X26

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

pfam05483
Location:1083 → 1273

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:2154 → 3049

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 254

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5119 → 5181

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4297 → 4512

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1481 → 2338

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1194 → 1358

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:5196 → 5270

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain
XM_036158554.1 → XP_036014447.1 dystonin isoform X27

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

smart00243
Location:5194 → 5266

GAS2; Growth-Arrest-Specific Protein 2 Domain

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:2154 → 3049

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5119 → 5181

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4297 → 4512

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1481 → 2338

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1207 → 1633

CCDC158; Coiled-coil domain-containing protein 158

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain

cd21236
Location:20 → 147

CH_DYST_rpt1; first calponin homology (CH) domain found in dystonin and similar proteins

cd21239
Location:152 → 255

CH_DYST_rpt2; second calponin homology (CH) domain found in dystonin and similar proteins
XM_017314868.2 → XP_017170357.1 dystonin isoform X28

UniProtKB/TrEMBL

A0A087WSP0

Conserved Domains (11) summary

pfam05483
Location:1083 → 1273

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:608 → 699

SPEC; Spectrin repeats

COG1196
Location:2154 → 3049

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:35 → 254

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:5010 → 5072

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4188 → 4403

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1481 → 2338

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:1194 → 1358

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:5087 → 5161

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:876 → 942

SH3_10; SH3 domain

pfam18373
Location:977 → 1054

Spectrin_like; Spectrin like domain
XM_017314750.3 → XP_017170239.1 dystonin isoform X17

Conserved Domains (12) summary

pfam05483
Location:1088 → 1278

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:613 → 704

SPEC; Spectrin repeats

COG1196
Location:4173 → 5068

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:28 → 259

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7138 → 7200

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6316 → 6531

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3489 → 4267

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1112 → 1550

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1778 → 1818

Plectin; Plectin repeat

pfam02187
Location:7215 → 7289

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:881 → 947

SH3_10; SH3 domain

pfam18373
Location:982 → 1059

Spectrin_like; Spectrin like domain
XM_006495679.4 → XP_006495742.1 dystonin isoform X19

Conserved Domains (12) summary

pfam05483
Location:996 → 1186

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:521 → 612

SPEC; Spectrin repeats

COG1196
Location:4081 → 4976

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:1 → 167

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00051
Location:7046 → 7108

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6224 → 6439

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3397 → 4175

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1020 → 1458

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1686 → 1726

Plectin; Plectin repeat

pfam02187
Location:7123 → 7197

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:789 → 855

SH3_10; SH3 domain

pfam18373
Location:890 → 967

Spectrin_like; Spectrin like domain
XM_006495669.5 → XP_006495732.1 dystonin isoform X10

Conserved Domains (12) summary

pfam05483
Location:1199 → 1389

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:724 → 815

SPEC; Spectrin repeats

COG1196
Location:4284 → 5179

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00014
Location:268 → 371

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00051
Location:7249 → 7311

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:6427 → 6642

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3600 → 4378

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:1223 → 1661

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1889 → 1929

Plectin; Plectin repeat

pfam02187
Location:7326 → 7400

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:992 → 1058

SH3_10; SH3 domain

pfam18373
Location:1093 → 1170

Spectrin_like; Spectrin like domain
XM_006495686.5 → XP_006495749.1 dystonin isoform X30

Conserved Domains (8) summary

smart00150
Location:282 → 373

SPEC; Spectrin repeats

smart00250
Location:2505 → 2542

PLEC; Plectin repeat

COG1196
Location:678 → 1404

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:375 → 564

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1098 → 1859

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:2468 → 2507

Plectin; Plectin repeat

pfam17902
Location:550 → 616

SH3_10; SH3 domain

pfam18373
Location:651 → 728

Spectrin_like; Spectrin like domain
XM_006495680.5 → XP_006495743.1 dystonin isoform X20

Conserved Domains (11) summary

pfam05483
Location:757 → 947

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:282 → 373

SPEC; Spectrin repeats

COG1196
Location:3842 → 4737

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:6807 → 6869

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:5985 → 6200

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:3158 → 3936

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:781 → 1219

CCDC158; Coiled-coil domain-containing protein 158

pfam00681
Location:1447 → 1487

Plectin; Plectin repeat

pfam02187
Location:6884 → 6958

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:550 → 616

SH3_10; SH3 domain

pfam18373
Location:651 → 728

Spectrin_like; Spectrin like domain
XM_006495685.2 → XP_006495748.1 dystonin isoform X29

UniProtKB/TrEMBL

A0A087WSP0

Related

ENSMUSP00000141127.2, ENSMUST00000185269.7

Conserved Domains (10) summary

pfam05483
Location:757 → 947

SCP-1; Synaptonemal complex protein 1 (SCP-1)

smart00150
Location:282 → 373

SPEC; Spectrin repeats

COG1196
Location:1828 → 2723

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:4793 → 4855

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:3971 → 4186

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1155 → 2012

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl02488
Location:868 → 1032

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam02187
Location:4870 → 4944

GAS2; Growth-Arrest-Specific Protein 2 Domain

pfam17902
Location:550 → 616

SH3_10; SH3 domain

pfam18373
Location:651 → 728

Spectrin_like; Spectrin like domain
XM_030246701.2 → XP_030102561.1 dystonin isoform X21

Conserved Domains (7) summary

smart00150
Location:5322 → 5449

SPEC; Spectrin repeats

COG1196
Location:2518 → 3413

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00051
Location:5483 → 5545

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:4661 → 4876

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1834 → 2612

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam00681
Location:123 → 163

Plectin; Plectin repeat

pfam02187
Location:5560 → 5634

GAS2; Growth-Arrest-Specific Protein 2 Domain