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    MIY2 ubiquitinyl hydrolase 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855910, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MIY2
    Official Full Name
    ubiquitinyl hydrolase 1
    Primary source
    SGD:S000006112
    Locus tag
    YPL191C
    See related
    AllianceGenome:SGD:S000006112; FungiDB:YPL191C; VEuPathDB:YPL191C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MIY1
    Summary
    Enables K48-linked deubiquitinase activity. Involved in protein K48-linked deubiquitination. Located in cell periphery and endoplasmic reticulum. Orthologous to several human genes including MINDY1 (MINDY lysine 48 deubiquitinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MIY2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (183597..184679, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rsa1p Neighboring gene pheromone-regulated protein PRM3 Neighboring gene Nab3p Neighboring gene Coa2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The budding index of Saccharomyces cerevisiae deletion strains identifies genes important for cell cycle progression. Zettel MF, et al. FEMS Microbiol Lett, 2003 Jun 27. PMID 12829295
    2. MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes. Abdul Rehman SA, et al. Mol Cell, 2016 Jul 7. PMID 27292798, Free PMC Article
    3. Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation. Li Y, et al. iScience, 2020 Apr 24. PMID 32240951, Free PMC Article
    4. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Bussey H, et al. Nature, 1997 May 29. PMID 9169875

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables K48-linked deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitinyl hydrolase 1
    NP_015133.1
    • K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      183597..184679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184005.1 → NP_015133.1  TPA: ubiquitinyl hydrolase 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3H7, Q08930
      UniProtKB/TrEMBL
      A6ZW62, B3LKN7, B5VSY5, C7GTT3, G2WNZ2, N1NY00
      Conserved Domains (2) summary
      TIGR00570
      Location:213 → 352
      cdk7; CDK-activating kinase assembly factor MAT1
      pfam04424
      Location:51 → 150
      MINDY_DUB; MINDY deubiquitinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08930.1

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