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    Msl2 MSL complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 77853, updated on 9-Dec-2024

    Summary

    Official Symbol
    Msl2provided by MGI
    Official Full Name
    MSL complex subunit 2provided by MGI
    Primary source
    MGI:MGI:1925103
    See related
    Ensembl:ENSMUSG00000066415 AllianceGenome:MGI:1925103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Msl2l1; Rnf184; E130103E02Rik
    Summary
    Enables histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Involved in epigenetic regulation of gene expression and positive regulation of DNA-templated transcription. Part of MSL complex. Is active in nucleus. Is expressed in embryo. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.4), spleen adult (RPKM 9.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Msl2 in Genome Data Viewer
    Location:
    9 E4; 9 53.17 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100956107..100981999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (101074054..101104800)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:100965416-100965626 Neighboring gene STARR-seq mESC enhancer starr_25047 Neighboring gene brain expressed X-linked 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5097 Neighboring gene predicted gene, 46140 Neighboring gene protein phosphatase 2, regulatory subunit B'', alpha Neighboring gene predicted gene, 24338 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2B ubiquitin ligase activity PubMed 
    enables histone H2B ubiquitin ligase activity  
    enables histone H2B ubiquitin ligase activity  
    enables metal ion binding  
    enables promoter-enhancer loop anchoring activity PubMed 
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    enables ubiquitin protein ligase activity  
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in epigenetic regulation of gene expression PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in protein monoubiquitination  
    involved_in protein monoubiquitination  
    involved_in protein ubiquitination  
    Component Evidence Code Pubs
    part_of MSL complex  
    part_of MSL complex PubMed 
    part_of MSL complex PubMed 
    part_of MSL complex  
    part_of MSL complex  
    is_active_in chromatin  
    is_active_in chromatin  
    is_active_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MSL2
    Names
    E3 ubiquitin-protein transferase MSL2
    MSL2-like 1
    male-specific lethal 2 homolog
    male-specific lethal 2-like 1
    male-specific lethal-2 homolog 1
    ring finger protein 184
    NP_001093921.1
    NP_001366273.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100451.2NP_001093921.1  E3 ubiquitin-protein ligase MSL2 isoform 1

      See identical proteins and their annotated locations for NP_001093921.1

      Status: VALIDATED

      Source sequence(s)
      AK035934, BC070432, BC100371, BE986573
      Consensus CDS
      CCDS85717.1
      UniProtKB/Swiss-Prot
      Q497U7, Q69ZF8, Q8CBI7
      Related
      ENSMUSP00000082270.4, ENSMUST00000085177.5
      Conserved Domains (2) summary
      cd13122
      Location:456505
      MSL2_CXC; DNA-binding cysteine-rich domain of male-specific lethal 2 and related proteins
      pfam16685
      Location:42111
      zf-RING_10; zinc RING finger of MSL2
    2. NM_001379344.1NP_001366273.1  E3 ubiquitin-protein ligase MSL2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC242670, AC242673
      Conserved Domains (3) summary
      TIGR03551
      Location:170212
      F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit
      pfam16682
      Location:381435
      MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2
      cl17238
      Location:137
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      100956107..100981999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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