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    Zfp433 zinc finger protein 433 [ Mus musculus (house mouse) ]

    Gene ID: 73610, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp433provided by MGI
    Official Full Name
    zinc finger protein 433provided by MGI
    Primary source
    MGI:MGI:1920860
    See related
    Ensembl:ENSMUSG00000096795 AllianceGenome:MGI:1920860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700123A16Rik
    Summary
    Predicted to enable DNA binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and protein-macromolecule adaptor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including ZNF234 (zinc finger protein 234); ZNF254 (zinc finger protein 254); and ZNF28 (zinc finger protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 1.9), CNS E11.5 (RPKM 1.8) and 24 other tissues See more
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    Genomic context

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    See Zfp433 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81540581..81562021)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81704747..81721976)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6889 Neighboring gene STARR-seq mESC enhancer starr_27348 Neighboring gene predicted gene 10778 Neighboring gene predicted gene, 51792 Neighboring gene predicted gene 8112 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 3055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 433

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243067.1 → NP_001229996.1  zinc finger protein 433 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC167202, BC064812, CN539577
      Consensus CDS
      CCDS78872.1
      UniProtKB/TrEMBL
      A0A0J9YUD4
      Related
      ENSMUSP00000144123.2, ENSMUST00000200889.4
      Conserved Domains (5) summary
      smart00349
      Location:4 → 52
      KRAB; krueppel associated box
      COG5048
      Location:160 → 575
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:164 → 184
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:512 → 537
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001379378.1 → NP_001366307.1  zinc finger protein 433 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167202
      Related
      ENSMUSP00000082807.6, ENSMUST00000085664.6
      Conserved Domains (2) summary
      COG5048
      Location:128 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81540581..81562021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156045.1 → XP_036011938.1  zinc finger protein 433 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:179 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 63
      KRAB; KRAB box
      pfam13465
      Location:139 → 164
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011243587.4 → XP_011241889.1  zinc finger protein 433 isoform X1

      See identical proteins and their annotated locations for XP_011241889.1

      Conserved Domains (4) summary
      COG5048
      Location:179 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 63
      KRAB; KRAB box
      pfam13465
      Location:139 → 164
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011243588.4 → XP_011241890.1  zinc finger protein 433 isoform X1

      See identical proteins and their annotated locations for XP_011241890.1

      Conserved Domains (4) summary
      COG5048
      Location:179 → 594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:23 → 63
      KRAB; KRAB box
      pfam13465
      Location:139 → 164
      zf-H2C2_2; Zinc-finger double domain

    4. XM_017314124.3 → XP_017169613.1  zinc finger protein 433 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:128 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036156046.1 → XP_036011939.1  zinc finger protein 433 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:128 → 543
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:132 → 152
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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