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    Edc3 enhancer of mRNA decapping 3 [ Mus musculus (house mouse) ]

    Gene ID: 353190, updated on 9-Dec-2024

    Summary

    Official Symbol
    Edc3provided by MGI
    Official Full Name
    enhancer of mRNA decapping 3provided by MGI
    Primary source
    MGI:MGI:2142951
    See related
    Ensembl:ENSMUSG00000038957 AllianceGenome:MGI:2142951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Yjdc; Lsm16
    Summary
    Predicted to enable identical protein binding activity and mRNA binding activity. Predicted to be involved in P-body assembly and deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in P-body. Is expressed in cerebellum; embryo; hippocampus; retina inner nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 50. Orthologous to human EDC3 (enhancer of mRNA decapping 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.6), whole brain E14.5 (RPKM 10.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Edc3 in Genome Data Viewer
    Location:
    9 B; 9 31.37 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57615823..57659782)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57708540..57750163)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Cyp1a2 5' enhancer Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene Cyp1a1 5' regulatory region Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E11409 Neighboring gene CDC-like kinase 3 Neighboring gene CapStarr-seq enhancers MGSCv37_chr9:57617333-57617516 and MGSCv37_chr9:57617555-57617846 Neighboring gene predicted gene, 32510 Neighboring gene AT-rich interaction domain 3B Neighboring gene STARR-seq mESC enhancer starr_24247 Neighboring gene STARR-positive B cell enhancer ABC_E2889 Neighboring gene STARR-positive B cell enhancer ABC_E6741

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables mRNA binding  
    enables mRNA binding  
    Component Evidence Code Pubs
    is_active_in P-body  
    located_in P-body  
    located_in cytoplasmic ribonucleoprotein granule  

    General protein information

    Preferred Names
    enhancer of mRNA-decapping protein 3
    Names
    enhancer of mRNA decapping 3 homolog
    yjeF domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410071.1NP_001397000.1  enhancer of mRNA-decapping protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      UniProtKB/Swiss-Prot
      Q3THV7, Q8K2D3
      UniProtKB/TrEMBL
      A0ELI5
    2. NM_001410073.1NP_001397002.1  enhancer of mRNA-decapping protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122515
    3. NM_153799.4NP_722494.1  enhancer of mRNA-decapping protein 3 isoform 1

      See identical proteins and their annotated locations for NP_722494.1

      Status: VALIDATED

      Source sequence(s)
      AC122515
      Consensus CDS
      CCDS23231.1
      UniProtKB/Swiss-Prot
      Q3THV7, Q8K2D3
      UniProtKB/TrEMBL
      A0ELI5
      Related
      ENSMUSP00000049146.8, ENSMUST00000043990.14
      Conserved Domains (4) summary
      cd01737
      Location:466
      LSm16_N; Like-Sm protein 16, N-terminal domain
      pfam03853
      Location:302455
      YjeF_N; YjeF-related protein N-terminus
      pfam09532
      Location:200300
      FDF; FDF domain
      pfam16598
      Location:102197
      Edc3_linker; Linker region of enhancer of mRNA-decapping protein 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57615823..57659782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155089.1XP_036010982.1  enhancer of mRNA-decapping protein 3 isoform X1

      Conserved Domains (4) summary
      cd01737
      Location:466
      LSm16_N; Like-Sm protein 16, N-terminal domain
      pfam09532
      Location:200300
      FDF; FDF domain
      pfam03853
      Location:302455
      YjeF_N; YjeF-related protein N-terminus
      pfam16598
      Location:102197
      Edc3_linker; Linker region of enhancer of mRNA-decapping protein 3
    2. XM_036155091.1XP_036010984.1  enhancer of mRNA-decapping protein 3 isoform X3

      Conserved Domains (3) summary
      pfam09532
      Location:17117
      FDF; FDF domain
      pfam03853
      Location:119272
      YjeF_N; YjeF-related protein N-terminus
      pfam16598
      Location:114
      Edc3_linker; Linker region of enhancer of mRNA-decapping protein 3
    3. XM_036155090.1XP_036010983.1  enhancer of mRNA-decapping protein 3 isoform X1

      Conserved Domains (4) summary
      cd01737
      Location:466
      LSm16_N; Like-Sm protein 16, N-terminal domain
      pfam09532
      Location:200300
      FDF; FDF domain
      pfam03853
      Location:302455
      YjeF_N; YjeF-related protein N-terminus
      pfam16598
      Location:102197
      Edc3_linker; Linker region of enhancer of mRNA-decapping protein 3
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