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    Pom121l2 POM121 transmembrane nucleoporin like 2 [ Mus musculus (house mouse) ]

    Gene ID: 195236, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pom121l2provided by MGI
    Official Full Name
    POM121 transmembrane nucleoporin like 2provided by MGI
    Primary source
    MGI:MGI:2684870
    See related
    Ensembl:ENSMUSG00000016982 AllianceGenome:MGI:2684870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm24
    Summary
    Predicted to enable nuclear localization sequence binding activity. Predicted to be a structural constituent of nuclear pore. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to be part of nuclear pore. Orthologous to human POM121L2 (POM121 transmembrane nucleoporin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 35.1) See more
    Orthologs
    human all
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    Genomic context

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    See Pom121l2 in Genome Data Viewer
    Location:
    13 A3.1; 13 8.11 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (22165351..22172904)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21981181..21988734)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 22 (anticodon TTT) Neighboring gene STARR-positive B cell enhancer ABC_E7210 Neighboring gene nuclear encoded tRNA methionine 8 (anticodon CAT) Neighboring gene nuclear encoded tRNA serine 8 (anticodon GCT) Neighboring gene nuclear encoded tRNA glutamine 1 (anticodon CTG)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    POM121-like protein 2
    Names
    POM121 membrane glycoprotein-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162928.1 → NP_001156400.1  POM121-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001156400.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL589879, AL590614, AL606968
      Consensus CDS
      CCDS49217.1
      UniProtKB/Swiss-Prot
      Q5SW25
      Related
      ENSMUSP00000017126.5, ENSMUST00000017126.6
      Conserved Domains (2) summary
      PHA03255
      Location:627 → 756
      PHA03255; BDLF3; Provisional
      pfam15229
      Location:164 → 341
      POM121; POM121 family

    2. NM_001162929.1 → NP_001156401.1  POM121-like protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001156401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) has a substantially shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK133022
      Consensus CDS
      CCDS49216.1
      UniProtKB/TrEMBL
      Q3V0N0
      Related
      ENSMUSP00000113688.2, ENSMUST00000117882.2
      Conserved Domains (1) summary
      pfam15229
      Location:164 → 341
      POM121; POM121 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      22165351..22172904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW25.1 GenPept UniProtKB/Swiss-Prot:Q5SW25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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