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    Tbx22 T-box 22 [ Mus musculus (house mouse) ]

    Gene ID: 245572, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbx22provided by MGI
    Official Full Name
    T-box 22provided by MGI
    Primary source
    MGI:MGI:2389465
    See related
    Ensembl:ENSMUSG00000031241 AllianceGenome:MGI:2389465
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D230020M15Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch mesenchyme; alimentary system; face; nose; and vibrissa follicle. Used to study X-linked cleft palate with or without ankyloglossia. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Tbx22 in Genome Data Viewer
    Location:
    X D; X 47.59 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106711570..106732586)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107667964..107688980)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47744 Neighboring gene integral membrane protein 2A Neighboring gene STARR-seq mESC enhancer starr_47745 Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-seq mESC enhancer starr_47746 Neighboring gene STARR-seq mESC enhancer starr_47747 Neighboring gene STARR-seq mESC enhancer starr_47748 Neighboring gene charged multivesicular body protein 1B2 Neighboring gene terminal nucleotidyltransferase 5D Neighboring gene STARR-seq mESC enhancer starr_47749 Neighboring gene STARR-seq mESC enhancer starr_47750 Neighboring gene STARR-seq mESC enhancer starr_47751 Neighboring gene WAVE homology in membrane protrusions

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in chromatin  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    T-box transcription factor TBX22
    Names
    T-box protein 22

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290747.1NP_001277676.1  T-box transcription factor TBX22 isoform 3

      See identical proteins and their annotated locations for NP_001277676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF516208, AK053430, BB375235, BC152402
      Consensus CDS
      CCDS72420.1
      UniProtKB/TrEMBL
      Q8BKE4
      Related
      ENSMUSP00000127321.2, ENSMUST00000168403.2
      Conserved Domains (1) summary
      cl00145
      Location:782
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    2. NM_145224.3NP_660259.1  T-box transcription factor TBX22 isoform 1

      See identical proteins and their annotated locations for NP_660259.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform 1.
      Source sequence(s)
      AF516208, AK084312, AL663048
      Consensus CDS
      CCDS30350.1
      UniProtKB/Swiss-Prot
      Q8K402
      UniProtKB/TrEMBL
      Q811Z5
      Related
      ENSMUSP00000112544.2, ENSMUST00000118986.8
      Conserved Domains (1) summary
      cd00182
      Location:89284
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    3. NM_181319.5NP_851836.2  T-box transcription factor TBX22 isoform 2

      See identical proteins and their annotated locations for NP_851836.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AF516208
      Consensus CDS
      CCDS30351.2
      UniProtKB/TrEMBL
      E9Q5R8, Q811Z5
      Related
      ENSMUSP00000128247.3, ENSMUST00000168174.9
      Conserved Domains (1) summary
      cd00182
      Location:103298
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      106711570..106732586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318490.3XP_017173979.1  T-box transcription factor TBX22 isoform X1

      UniProtKB/TrEMBL
      Q811Z5
      Conserved Domains (1) summary
      cd00182
      Location:90285
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    2. XM_017318491.3XP_017173980.1  T-box transcription factor TBX22 isoform X2

      UniProtKB/Swiss-Prot
      Q8K402
      UniProtKB/TrEMBL
      Q811Z5
      Conserved Domains (1) summary
      cd00182
      Location:89284
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    3. XM_017318492.3XP_017173981.1  T-box transcription factor TBX22 isoform X3

      UniProtKB/TrEMBL
      Q811Z5
      Conserved Domains (1) summary
      cd00182
      Location:1167
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    4. XM_006528040.5XP_006528103.1  T-box transcription factor TBX22 isoform X4

      See identical proteins and their annotated locations for XP_006528103.1

      Conserved Domains (1) summary
      cl00145
      Location:1126
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    5. XM_006528039.4XP_006528102.1  T-box transcription factor TBX22 isoform X4

      See identical proteins and their annotated locations for XP_006528102.1

      Conserved Domains (1) summary
      cl00145
      Location:1126
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    6. XM_036161956.1XP_036017849.1  T-box transcription factor TBX22 isoform X5

      Conserved Domains (1) summary
      cl00145
      Location:167
      T-box; DNA-binding domain of the T-box transcription factor family
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