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    Hs3st2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 195646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs3st2provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 2provided by MGI
    Primary source
    MGI:MGI:1333802
    See related
    Ensembl:ENSMUSG00000046321 AllianceGenome:MGI:1333802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430516N12Rik; A830061E14Rik
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and skeleton. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.9), cortex adult (RPKM 2.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hs3st2 in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120990785..121196555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121391585..121501768)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20061 Neighboring gene predicted gene, 36736 Neighboring gene STARR-seq mESC enhancer starr_20062 Neighboring gene STARR-seq mESC enhancer starr_20063 Neighboring gene STARR-positive B cell enhancer mm9_chr7:128623661-128623961 Neighboring gene predicted gene, 39081 Neighboring gene RIKEN cDNA 4933432K03 gene Neighboring gene RIKEN cDNA 1700025J12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10470 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene STARR-positive B cell enhancer ABC_E6594 Neighboring gene STARR-positive B cell enhancer ABC_E8205 Neighboring gene STARR-seq mESC enhancer starr_20066 Neighboring gene sodium channel, nonvoltage-gated 1 gamma Neighboring gene predicted gene, 36848

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expanding the 3-O-Sulfate Proteome--Enhanced Binding of Neuropilin-1 to 3-O-Sulfated Heparan Sulfate Modulates Its Activity. Thacker BE, et al. ACS Chem Biol, 2016 Apr 15. PMID 26731579, Free PMC Article
    2. microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2. Zhang F, et al. Cell Signal, 2023 Feb. PMID 36423858
    3. Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. Liu J, et al. J Biol Chem, 1999 Feb 19. PMID 9988768
    4. Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. Hasegawa H, et al. J Comp Neurol, 2008 Dec 1. PMID 18839409, Free PMC Article
    5. Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain. Yabe T, et al. Glycobiology, 2005 Oct. PMID 15944372

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2.
      Title: microRNA-100 shuttled by human umbilical cord MSC-secreted extracellular vesicles induces endometriosis by inhibiting HS3ST2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 2
    Names
    heparan sulfate 3-O-sulfotransferase 2
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
    NP_001074796.1
    NP_001406126.1
    XP_006507527.1
    XP_006507529.1
    XP_030098100.1
    XP_030098101.1
    XP_036008693.1
    XP_036008694.1
    XP_036008695.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081327.2 → NP_001074796.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_001074796.1

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331
      Consensus CDS
      CCDS40115.1
      UniProtKB/Swiss-Prot
      Q673U1, Q8BLP1, Q8C055
      Related
      ENSMUSP00000081678.4, ENSMUST00000084628.5
      Conserved Domains (1) summary
      pfam00685
      Location:114 → 351
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001419197.1 → NP_001406126.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331

    RNA

    1. NR_185034.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098715, AC125331

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120990785..121196555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152801.1 → XP_036008694.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

      Conserved Domains (1) summary
      pfam00685
      Location:2 → 187
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_030242240.2 → XP_030098100.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X6

      Conserved Domains (1) summary
      pfam00685
      Location:2 → 187
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_036152802.1 → XP_036008695.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X7

      Conserved Domains (1) summary
      cl21551
      Location:131 → 181
      Sulfotransfer_3; Sulfotransferase family

    4. XM_006507464.1 → XP_006507527.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:131 → 368
      Sulfotransfer_1; Sulfotransferase domain

    5. XM_030242241.1 → XP_030098101.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X8

      Conserved Domains (1) summary
      cl21551
      Location:131 → 184
      Sulfotransfer_3; Sulfotransferase family

    6. XM_006507466.4 → XP_006507529.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4

      Conserved Domains (1) summary
      cl21551
      Location:131 → 178
      Sulfotransfer_3; Sulfotransferase family

    7. XM_036152800.1 → XP_036008693.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

      Conserved Domains (1) summary
      cl21551
      Location:131 → 182
      Sulfotransfer_3; Sulfotransferase family

    RNA

    1. XR_004934044.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177575.2: Suppressed sequence

      Description
      NM_177575.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q673U1.2 GenPept UniProtKB/Swiss-Prot:Q673U1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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