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    Rxfp1 relaxin/insulin-like family peptide receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 381489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rxfp1provided by MGI
    Official Full Name
    relaxin/insulin-like family peptide receptor 1provided by MGI
    Primary source
    MGI:MGI:2682211
    See related
    Ensembl:ENSMUSG00000034009 AllianceGenome:MGI:2682211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lgr7; Gm1018
    Summary
    Enables hormone binding activity. Acts upstream of or within several processes, including lung connective tissue development; myofibroblast differentiation; and nipple morphogenesis. Predicted to be active in plasma membrane. Is expressed in brain; mandibular process; metanephros; and oral region epithelium. Orthologous to human RXFP1 (relaxin family peptide receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 9.6), cortex adult (RPKM 2.8) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rxfp1 in Genome Data Viewer
    Location:
    3 E3; 3 34.94 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79548910..79645258, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79641600..79737951, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene peptidylprolyl isomerase D (cyclophilin D) Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene STARR-seq mESC enhancer starr_08007 Neighboring gene VISTA enhancer mm1650 Neighboring gene STARR-seq mESC enhancer starr_08009 Neighboring gene transmembrane protein 144 Neighboring gene STARR-positive B cell enhancer ABC_E3438 Neighboring gene predicted gene, 26420 Neighboring gene STARR-seq mESC enhancer starr_08010 Neighboring gene STARR-seq mESC enhancer starr_08011 Neighboring gene STARR-seq mESC enhancer starr_08012 Neighboring gene golgi associated kinase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Anti-apoptotic and Matrix Remodeling Actions of a Small Molecule Agonist of the Human Relaxin Receptor, ML290 in Mice With Unilateral Ureteral Obstruction. Ng HH, et al. Front Physiol, 2021. PMID 34305630, Free PMC Article
    2. Localization of LGR7 gene expression in adult mouse brain using LGR7 knock-out/LacZ knock-in mice: correlation with LGR7 mRNA distribution. Piccenna L, et al. Ann N Y Acad Sci, 2005 May. PMID 15956708
    3. Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells. Ortinau S, et al. Ann N Y Acad Sci, 2005 May. PMID 15956710
    4. Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease. Samuel CS, et al. Endocrinology, 2009 Mar. PMID 18974264
    5. Alpha-adrenergic activation upregulates expression of relaxin receptor RXFP1 in cardiomyocytes. Moore XL, et al. Ann N Y Acad Sci, 2009 Apr. PMID 19416204

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
      Title: Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis.
    2. This study demonstrates the involvement of ADAM10 and PI3K/Akt signaling in mediating RLX-induced Notch-1 activation.
      Title: Relaxin induces up-regulation of ADAM10 metalloprotease in RXFP1-expressing cells by PI3K/AKT signaling.
    3. No differences were found in RXFP1 expression related to aging.
      Title: Differential effects of relaxin deficiency on vascular aging in arteries of male mice.
    4. Colonic tissue expresses RXFP1 in smooth muscle cells of the muscular wall and in neurons of the myenteric plexus.
      Title: Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon.
    5. relaxin/RXFP1 signaling in smooth muscle cells is important for normal collagen turnover and relaxation of the pubic symphysis during pregnancy
      Title: Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice.
    6. Rxfp1, Rxfp2, and Nr3c1 mRNAs were expressed on the developing maxilla and mandible, Meckel's cartilage, tongue, and tooth primordia between mouse embryonic days 13.5-18.5.
      Title: Relaxin receptors 1 and 2 and nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) mRNAs are expressed in oral components of developing mice.
    7. maternal exposure to simazine causes disturbed relaxin signaling pathway and testicular dysfunction
      Title: Disturbed relaxin signaling pathway and testicular dysfunction in mouse offspring upon maternal exposure to simazine.
    8. H3 relaxin exerts antifibrotic actions via RXFP1 receptor
      Title: H3 relaxin demonstrates antifibrotic properties via the RXFP1 receptor.
    9. The downregulation of RXFP1 resulted in significant decrease in metastasis rate in PC3 tumors.
      Title: Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis.
    10. Rxfp1 acts in an autocrine and/or paracrine fashion upstream of PCDHY in regulating increased canonical Wnt signaling in prostate cancer.
      Title: Relaxin drives Wnt signaling through upregulation of PCDHY in prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lung connective tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myofibroblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nipple morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    relaxin receptor 1
    Names
    leucine-rich repeat-containing 7
    leucine-rich repeat-containing G-protein coupled receptor 7
    relaxin family peptide receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212452.3 → NP_997617.1  relaxin receptor 1 precursor

      See identical proteins and their annotated locations for NP_997617.1

      Status: VALIDATED

      Source sequence(s)
      AC122462, AC159281
      Consensus CDS
      CCDS17420.1
      UniProtKB/Swiss-Prot
      Q6R6I7, Q80UD3
      Related
      ENSMUSP00000077611.6, ENSMUST00000078527.13
      Conserved Domains (6) summary
      cd00112
      Location:27 → 62
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00116
      Location:147 → 331
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:110 → 127
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:128 → 151
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:422 → 681
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:151 → 210
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      79548910..79645258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252661.2 → XP_030108521.1  relaxin receptor 1 isoform X2

      Conserved Domains (5) summary
      sd00033
      Location:2 → 22
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:22 → 81
      LRR_8; Leucine rich repeat
      cd14964
      Location:279 → 303
      7tm_GPCRs; TM helix 1 [structural motif]
      NF033189
      Location:2 → 234
      internalin_A; class 1 internalin InlA
      cl28897
      Location:277 → 563
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006501629.3 → XP_006501692.1  relaxin receptor 1 isoform X1

      Conserved Domains (5) summary
      cd00112
      Location:27 → 62
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      sd00033
      Location:128 → 151
      LRR_RI; leucine-rich repeat [structural motif]
      cd15965
      Location:405 → 691
      7tmA_RXFP1_LGR7; relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors
      pfam13855
      Location:151 → 210
      LRR_8; Leucine rich repeat
      NF033189
      Location:126 → 334
      internalin_A; class 1 internalin InlA

    3. XM_030252662.2 → XP_030108522.1  relaxin receptor 1 isoform X3

      Conserved Domains (5) summary
      COG4886
      Location:9 → 145
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:20 → 43
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:43 → 102
      LRR_8; Leucine rich repeat
      cd14964
      Location:178 → 204
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:177 → 463
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6R6I7.1 GenPept UniProtKB/Swiss-Prot:Q6R6I7

    Gene LinkOut

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