U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tafa3 TAFA chemokine like family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 329731, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tafa3provided by MGI
    Official Full Name
    TAFA chemokine like family member 3provided by MGI
    Primary source
    MGI:MGI:3046463
    See related
    Ensembl:ENSMUSG00000055865 AllianceGenome:MGI:3046463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sam3; Tafa-3; Fam19a3; 7530404M11Rik
    Summary
    This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis adult (RPKM 2.5), heart adult (RPKM 0.9) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tafa3 in Genome Data Viewer
    Location:
    3 F2.2; 3 45.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104674721..104686854, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104767405..104779542, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24223 Neighboring gene STARR-positive B cell enhancer mm9_chr3:104518140-104518441 Neighboring gene STARR-seq mESC enhancer starr_08619 Neighboring gene predicted gene 6485 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene ras homolog family member C

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Deficiency of a brain-specific chemokine-like molecule, SAM3, induces cardinal phenotypes of autism spectrum disorders in mice. Kim S, et al. Sci Rep, 2017 Nov 28. PMID 29184127, Free PMC Article
    2. FAM19A3, a novel secreted protein, modulates the microglia/macrophage polarization dynamics and ameliorates cerebral ischemia. Shao Y, et al. FEBS Lett, 2015 Feb 13. PMID 25595455
    3. Tafa-3 encoding for a secretory peptide is expressed in the mouse pars tuberalis and is affected by melatonin 1 receptor deficiency. Fischer C, et al. Gen Comp Endocrinol, 2012 May 15. PMID 22426341
    4. TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain. Tom Tang Y, et al. Genomics, 2004 Apr. PMID 15028294
    5. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Lees-Murdock DJ, et al. Genomics, 2004 Jul. PMID 15203217

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that TAFA-3 is a signaling molecule from the hypophysial pars tuberalis.
      Title: Tafa-3 encoding for a secretory peptide is expressed in the mouse pars tuberalis and is affected by melatonin 1 receptor deficiency.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of microglial cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of microglial cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microglial cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of microglial cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    chemokine-like protein TAFA-3
    Names
    family with sequence similarity 19, member A3
    protein FAM19A3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183224.3 → NP_899047.1  chemokine-like protein TAFA-3 precursor

      See identical proteins and their annotated locations for NP_899047.1

      Status: REVIEWED

      Source sequence(s)
      AC171110, AK078681
      Consensus CDS
      CCDS51032.1
      UniProtKB/Swiss-Prot
      Q147Z7, Q7TPG6
      Related
      ENSMUSP00000123514.2, ENSMUST00000139783.2
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 130
      TAFA; TAFA family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      104674721..104686854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163140.1 → XP_036019033.1  chemokine-like protein TAFA-3 isoform X1

      UniProtKB/Swiss-Prot
      Q147Z7, Q7TPG6
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 130
      TAFA; TAFA family

    2. XM_017319626.3 → XP_017175115.1  chemokine-like protein TAFA-3 isoform X1

      UniProtKB/Swiss-Prot
      Q147Z7, Q7TPG6
      Conserved Domains (1) summary
      pfam12020
      Location:42 → 130
      TAFA; TAFA family

    3. XM_036163139.1 → XP_036019032.1  chemokine-like protein TAFA-3 isoform X2

      Conserved Domains (1) summary
      pfam12020
      Location:78 → 166
      TAFA; TAFA family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TPG6.1 GenPept UniProtKB/Swiss-Prot:Q7TPG6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools