Pid1 phosphotyrosine interaction domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pid1provided by MGI
Official Full Name: phosphotyrosine interaction domain containing 1provided by MGI
Primary source: MGI:MGI:2138391
See related: Ensembl:ENSMUSG00000045658 AllianceGenome:MGI:2138391
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NYGGF4; P-CLI1; 5033414K04Rik
Summary: Involved in several processes, including cellular response to cytokine stimulus; negative regulation of D-glucose import; and positive regulation of ATP biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system and retina. Orthologous to human PID1 (phosphotyrosine interaction domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 19.4), liver adult (RPKM 17.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C5; 1 43.14 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (84014014..84317550, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (84036293..84339842, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data provide evidence that PID1 serves as an insulin-regulated retention adaptor protein controlling translocation of LRP1 in conjunction with GLUT4 to the plasma membrane of adipocytes.
Title: PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles.
By acting as an insulin-dependent retention adaptor, PID1 serves as a regulator of LRP1 function controlling the disposal of postprandial lipoproteins.
Title: The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins.
Results thus indicate phosphotyrosine interaction domain containing 1 (PID1) as a critical regulator of glucose metabolism in adipocytes.
Title: PID1 in adipocytes modulates whole-body glucose homeostasis.
data demonstrate that differentially methylated genes are significantly overrepresented in NYGGF4-overexpression adipocytes, providing valuable clues for further exploration of the role of NYGGF4 in insulin sensitivity regulation.
Title: Genomic DNA methylation changes in NYGGF4-overexpression 3T3-L1 adipocytes.
These results suggested that addition of silencing NYGGF4 partly rescued the effect of insulin resistance and mitochondrial dysfunction in NYGGF4 silenced 3T3-L1 adipocytes incubated with cyanide p-trifluoromethoxyphenyl-hydrazone.
Title: Knockdown of NYGGF4 (PID1) rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes.
Lipoic acid protects 3T3-L1 adipocytes from NYGGF4-induced IR partially through increasing phosphorylation of IRS-1 and Akt
Title: α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt.
Data demonstrate that NYGGF4 knockdown increases glucose transport in myocytes by activation of the IRS-1/PI3K/AKT insulin pathway.
Title: Knockdown of NYGGF4 increases glucose transport in C2C12 mice skeletal myocytes by activation IRS-1/PI3K/AKT insulin pathway.
NYGGF4 reduced intracellular ATP concentration and promoted an increase in mitochondrial transmembrane potential and reactive oxygen species level without affecting mitochondrial morphology or mtDNA.
Title: Effects of NYGGF4 knockdown on insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes.
The expression of NYGGF4 mRNA is affected by a variety of factors that are related to insulin sensitivity.[NYGGF4]
Title: NYGGF4 homologous gene expression in 3T3-L1 adipocytes: regulation by FFA and adipokines.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

34.MMHAP70FLD4.seq (e-PCR)
- UniSTS:124107

RH125466 (e-PCR)
- UniSTS:162285

Ptrh2 (e-PCR), detects polymorphism
- UniSTS:516857

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fatty acid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-6	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to leptin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of D-glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of reactive oxygen species metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PTB-containing, cubilin and LRP1-interacting protein

Names: phosphotyrosine interaction domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003948.2 → NP_001003948.2 PTB-containing, cubilin and LRP1-interacting protein

See identical proteins and their annotated locations for NP_001003948.2

Status: VALIDATED

Source sequence(s)

AK083256, AK151267, BB370718, BY004446

Consensus CDS

CCDS15104.2

UniProtKB/Swiss-Prot

Q3UAR0, Q3UBG2, Q68EE9, Q7TPS1

Related

ENSMUSP00000127716.3, ENSMUST00000168574.9

Conserved Domains (1) summary

cd13167
Location:56 → 194

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

84014014..84317550 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313047.2 → XP_017168536.1 PTB-containing, cubilin and LRP1-interacting protein isoform X4

Conserved Domains (1) summary

cd13167
Location:68 → 202

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold
XM_036154693.1 → XP_036010586.1 PTB-containing, cubilin and LRP1-interacting protein isoform X5

Conserved Domains (1) summary

cd13167
Location:60 → 198

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold
XM_036154687.1 → XP_036010580.1 PTB-containing, cubilin and LRP1-interacting protein isoform X3

Conserved Domains (1) summary

cd13167
Location:86 → 220

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold
XM_011238718.4 → XP_011237020.1 PTB-containing, cubilin and LRP1-interacting protein isoform X2

Conserved Domains (1) summary

cd13167
Location:7 → 145

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold
XM_011238717.4 → XP_011237019.1 PTB-containing, cubilin and LRP1-interacting protein isoform X1

Conserved Domains (1) summary

cd13167
Location:82 → 216

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold
XM_036154689.1 → XP_036010582.1 PTB-containing, cubilin and LRP1-interacting protein isoform X4

Conserved Domains (1) summary

cd13167
Location:68 → 202

PTB_P-CLI1; PTB-containing, cubilin and LRP1-interacting protein Phosphotyrosine-binding (PTB) PH-like fold