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    Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 225028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Map4k3provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 3provided by MGI
    Primary source
    MGI:MGI:2154405
    See related
    Ensembl:ENSMUSG00000024242 AllianceGenome:MGI:2154405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glk; MEKKK3; MEKKK 3; MAPKKKK3; RAB8IPL1; 4833416M01Rik; 4833416M07Rik; 9530052P13Rik
    Summary
    Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 16.8), limb E14.5 (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map4k3 in Genome Data Viewer
    Location:
    17 E3; 17 50.97 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80887942..81039118, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80580513..80728806, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2500 Neighboring gene STARR-positive B cell enhancer ABC_E8925 Neighboring gene alkaline phosphatase, intestinal pseudogene Neighboring gene STARR-seq mESC enhancer starr_43318 Neighboring gene STARR-positive B cell enhancer ABC_E5633 Neighboring gene STARR-positive B cell enhancer ABC_E10973 Neighboring gene STARR-positive B cell enhancer ABC_E9172 Neighboring gene cyclin dependent kinase like 4 Neighboring gene STARR-positive B cell enhancer ABC_E4229 Neighboring gene STARR-positive B cell enhancer ABC_E616 Neighboring gene STARR-seq mESC enhancer starr_43322 Neighboring gene STARR-seq mESC enhancer starr_43326 Neighboring gene STARR-seq mESC enhancer starr_43329 Neighboring gene predicted gene 9959 Neighboring gene STARR-positive B cell enhancer mm9_chr17:81171844-81172145 Neighboring gene STARR-seq mESC enhancer starr_43332 Neighboring gene STARR-seq mESC enhancer starr_43333 Neighboring gene STARR-seq mESC enhancer starr_43334 Neighboring gene STARR-seq mESC enhancer starr_43335 Neighboring gene predicted gene, 33538 Neighboring gene predicted gene, 33596

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation. Chi JN, et al. Theranostics, 2022. PMID 35966593, Free PMC Article
    2. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells. Chuang HC, et al. Nat Immunol, 2011 Oct 9. PMID 21983831
    3. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Chuang HC, et al. Sci Adv, 2018 Sep. PMID 30214937, Free PMC Article
    4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation.
      Title: MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation.
    2. GLK induces IL-17A transcription by activating AhR and ROR-gammat.GLK controls IL-17A production and autoimmune responses through AhR.
      Title: GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 3
    Names
    MAPK/ERK kinase kinase kinase 3
    MEK kinase kinase 3
    germinal center kinase-related protein kinase
    NP_001277274.1
    NP_001347207.1
    XP_006524255.1
    XP_006524259.1
    XP_006524260.1
    XP_036016462.1
    XP_036016463.1
    XP_036016464.1
    XP_036016465.1
    XP_036016466.1
    XP_036016467.1
    XP_036016468.1
    XP_036016469.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290345.1 → NP_001277274.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_001277274.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA289270, AI430883, AK014711, AK079249, BQ442103, CD353921, CF167620, CK618209, CO433380
      Consensus CDS
      CCDS70847.1
      UniProtKB/Swiss-Prot
      E9PWI4, Q99JP0, Q9CUS8
      UniProtKB/TrEMBL
      E9QNE9
      Related
      ENSMUSP00000025089.8, ENSMUST00000025089.9
      Conserved Domains (2) summary
      smart00036
      Location:561 → 874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    2. NM_001360278.1 → NP_001347207.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC131712, AC169501
      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:551 → 864
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80887942..81039118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160575.1 → XP_036016468.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:522 → 865
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    2. XM_006524197.4 → XP_006524260.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

      UniProtKB/TrEMBL
      A0A3Q4EGQ9, E9QNE9
      Related
      ENSMUSP00000157308.2, ENSMUST00000234133.2
      Conserved Domains (2) summary
      smart00036
      Location:540 → 853
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    3. XM_036160574.1 → XP_036016467.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:540 → 883
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    4. XM_036160572.1 → XP_036016465.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:551 → 894
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    5. XM_006524196.4 → XP_006524259.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:543 → 856
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    6. XM_036160573.1 → XP_036016466.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:543 → 886
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    7. XM_036160570.1 → XP_036016463.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:561 → 904
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    8. XM_036160571.1 → XP_036016464.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:554 → 897
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    9. XM_006524192.4 → XP_006524255.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:572 → 885
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    10. XM_036160569.1 → XP_036016462.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:572 → 915
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    11. XM_036160576.1 → XP_036016469.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

      UniProtKB/TrEMBL
      E9QNE9
      Conserved Domains (2) summary
      smart00036
      Location:483 → 826
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 184
      PKc_like; Protein Kinases, catalytic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081357.1: Suppressed sequence

      Description
      NM_001081357.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JP0.4 GenPept UniProtKB/Swiss-Prot:Q99JP0

    Gene LinkOut

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