Stoml2 stomatin (Epb7.2)-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stoml2provided by MGI
Official Full Name: stomatin (Epb7.2)-like 2provided by MGI
Primary source: MGI:MGI:1913842
See related: Ensembl:ENSMUSG00000028455 AllianceGenome:MGI:1913842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MSLP2; SLP-2; 0610038F01Rik
Summary: Predicted to enable GTPase binding activity; T cell receptor binding activity; and cardiolipin binding activity. Involved in several processes, including positive regulation of interleukin-2 production; proton motive force-driven mitochondrial ATP synthesis; and stress-induced mitochondrial fusion. Located in mitochondrion and plasma membrane. Orthologous to human STOML2 (stomatin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 48.2), CNS E11.5 (RPKM 43.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 22.99 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43027690..43031402, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43027690..43031976, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

resting or activated T cells from T cell-specific Slp-2 knockout mice showed a significant impairment in the production of several mitochondrial DNA-encoded polypeptides following T cell activation. Measurement of mitochondrial DNA stability and mitochondrial transcription revealed that this impairment was at the post-transcriptional level.
Title: Stomatin-like protein 2 deficiency results in impaired mitochondrial translation.
Slp2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans
Title: Stomatin-like protein 2 is involved in endometrial stromal cell proliferation and differentiation during decidualization in mice and humans.
SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response.
Title: Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling.
Findings identify SLP-2 as a key regulator of the formation of respiratory chain supercomplex in vivo and show that these supercomplexes are required for optimal cell function.
Title: Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables cardiolipin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in CD4-positive, alpha-beta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein complex oligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein complex oligomerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stress-induced mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stomatin-like protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419082.1 → NP_001406011.1 stomatin-like protein 2, mitochondrial isoform a

Status: VALIDATED

Source sequence(s)

AL672276
NM_001419083.1 → NP_001406012.1 stomatin-like protein 2, mitochondrial isoform b precursor

Status: VALIDATED

Source sequence(s)

AL672276
NM_001419084.1 → NP_001406013.1 stomatin-like protein 2, mitochondrial isoform d

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/TrEMBL

A2AG39
NM_001419085.1 → NP_001406014.1 stomatin-like protein 2, mitochondrial isoform e

Status: VALIDATED

Source sequence(s)

AL672276

UniProtKB/TrEMBL

A2AG39

Related

ENSMUSP00000117586.2, ENSMUST00000136326.8
NM_001419086.1 → NP_001406015.1 stomatin-like protein 2, mitochondrial isoform f

Status: VALIDATED

Source sequence(s)

AL672276
NM_001419087.1 → NP_001406016.1 stomatin-like protein 2, mitochondrial isoform f

Status: VALIDATED

Source sequence(s)

AL672276
NM_001419088.1 → NP_001406017.1 stomatin-like protein 2, mitochondrial isoform f

Status: VALIDATED

Source sequence(s)

AL672276
NM_023231.3 → NP_075720.1 stomatin-like protein 2, mitochondrial isoform c

See identical proteins and their annotated locations for NP_075720.1

Status: VALIDATED

Source sequence(s)

AL672276

Consensus CDS

CCDS18089.1

UniProtKB/Swiss-Prot

Q99JB2, Q9DCG8

UniProtKB/TrEMBL

A2AG39

Related

ENSMUSP00000030169.9, ENSMUST00000030169.15

Conserved Domains (2) summary

COG0330
Location:38 → 314

HflC; Regulator of protease activity HflC, stomatin/prohibitin superfamily [Posttranslational modification, protein turnover, chaperones]

cd08829
Location:74 → 184

SPFH_paraslipin; Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily