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    Cimap3 ciliary microtubule associated protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 100503311, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cimap3provided by MGI
    Official Full Name
    ciliary microtubule associated protein 3provided by MGI
    Primary source
    MGI:MGI:1923670
    See related
    Ensembl:ENSMUSG00000010136 AllianceGenome:MGI:1923670
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pifo; 1700027A23Rik
    Summary
    Enables cytoskeletal protein binding activity and enzyme binding activity. Involved in regulation of cell projection organization. Acts upstream of or within with a positive effect on cilium organization. Acts upstream of or within embryonic heart tube left/right pattern formation. Located in ciliary basal body; nucleus; and trans-Golgi network. Is expressed in several structures, including brain ventricle and choroid plexus; embryo ectoderm; nasal cavity epithelium; testis; and upper jaw. Orthologous to human CIMAP3 (ciliary microtubule associated protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 31.5), lung adult (RPKM 2.0) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Cimap3 in Genome Data Viewer
    Location:
    3 F2.2; 3 46.47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105904273..105921962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105996957..106014646, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 77 Neighboring gene oviductal glycoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E6099 Neighboring gene STARR-seq mESC enhancer starr_08642 Neighboring gene predicted gene 42722 Neighboring gene chitinase-like 5 Neighboring gene predicted gene 4540

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Clone Names

    • MGC58817

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-tubulin binding PubMed 
    enables beta-tubulin binding  
    enables cytoskeletal protein binding  
    enables gamma-tubulin binding PubMed 
    enables gamma-tubulin binding  
    enables kinesin binding PubMed 
    enables kinesin binding  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables small GTPase binding PubMed 
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in Golgi stack  
    located_in ciliary basal body PubMed 
    located_in cytoplasmic vesicle  
    located_in nucleus PubMed 
    located_in trans-Golgi network PubMed 

    General protein information

    Preferred Names
    ciliary microtubule-associated protein 3
    Names
    pitchfork
    primary cilia formation
    protein pitchfork

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001200028.1NP_001186957.1  ciliary microtubule-associated protein 3 isoform a

      See identical proteins and their annotated locations for NP_001186957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AW492850, HM237138
      Consensus CDS
      CCDS51038.1
      UniProtKB/Swiss-Prot
      Q9D9W1
      Related
      ENSMUSP00000010280.5, ENSMUST00000010280.11
    2. NM_029604.3NP_083880.2  ciliary microtubule-associated protein 3 isoform b

      See identical proteins and their annotated locations for NP_083880.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK006407, AW492850, AW519725
      Consensus CDS
      CCDS51037.1
      UniProtKB/Swiss-Prot
      D9J0A0, D9J0A1, Q810M7, Q9D9W1
      Related
      ENSMUSP00000069454.7, ENSMUST00000066319.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      105904273..105921962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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