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    Tmt1a2 thiol methyltransferase 1A2 [ Mus musculus (house mouse) ]

    Gene ID: 393082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmt1a2provided by MGI
    Official Full Name
    thiol methyltransferase 1A2provided by MGI
    Primary source
    MGI:MGI:3026615
    See related
    Ensembl:ENSMUSG00000056487 AllianceGenome:MGI:3026615
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubie; Gm921; UbiE2; Mettl7a2
    Summary
    Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: GeneID 393082 represents a single gene, Ubie. Although the official gene name is "UbiE-YGHL1 fusion protein", this gene encodes the Ubie protein. The UbiE-YGHL1 fusion protein is represented by GeneID 554292. [20 Jul 2007]
    Expression
    Biased expression in kidney adult (RPKM 43.2), lung adult (RPKM 14.9) and 7 other tissues See more
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    Genomic context

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    See Tmt1a2 in Genome Data Viewer
    Location:
    15 F1; 15 56.27 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100251081..100259700)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100353200..100361819)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A1 Neighboring gene thiol methyltransferase 1A3 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene HIG1 domain family, member 1C Neighboring gene predicted gene, 53911 Neighboring gene solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E4149 Neighboring gene predicted gene 5475

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Readthrough Methig1

    Readthrough gene: Methig1, Included gene: Higd1c

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiol S-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lncRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thiol methyltransferase 1A2
    Names
    methyltransferase like 7A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199477.2 → NP_955771.2  thiol methyltransferase 1A2

      See identical proteins and their annotated locations for NP_955771.2

      Status: PROVISIONAL

      Source sequence(s)
      BC090971
      Consensus CDS
      CCDS27836.1
      UniProtKB/TrEMBL
      Q5I0W6, Q76I24
      Related
      ENSMUSP00000085467.6, ENSMUST00000088142.6
      Conserved Domains (2) summary
      COG0500
      Location:70 → 200
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08241
      Location:75 → 172
      Methyltransf_11; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100251081..100259700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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