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    Emc9 ER membrane protein complex subunit 9 [ Mus musculus (house mouse) ]

    Gene ID: 85308, updated on 27-Nov-2024

    Summary

    Official Symbol
    Emc9provided by MGI
    Official Full Name
    ER membrane protein complex subunit 9provided by MGI
    Primary source
    MGI:MGI:1934682
    See related
    Ensembl:ENSMUSG00000022217 AllianceGenome:MGI:1934682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgi112; Fam158a; 1500005A01Rik
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in cytoplasm. Predicted to be part of EMC complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human EMC9 (ER membrane protein complex subunit 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.3), subcutaneous fat pad adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Emc9 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55818976..55822832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55581519..55585375, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene ring finger protein 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of EMC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ER membrane protein complex subunit 9
    Names
    UPF0172 protein FAM158A
    family with sequence similarity 158, member A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418787.1NP_001405716.1  ER membrane protein complex subunit 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC174678
    2. NM_001418788.1NP_001405717.1  ER membrane protein complex subunit 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC174678
    3. NM_001418789.1NP_001405718.1  ER membrane protein complex subunit 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC174678
      Related
      ENSMUSP00000133463.2, ENSMUST00000174352.8
    4. NM_001418790.1NP_001405719.1  ER membrane protein complex subunit 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC174678
    5. NM_033146.2NP_149158.1  ER membrane protein complex subunit 9 isoform 1

      See identical proteins and their annotated locations for NP_149158.1

      Status: VALIDATED

      Source sequence(s)
      AC174678
      Consensus CDS
      CCDS27117.1
      UniProtKB/Swiss-Prot
      Q9DB76
      UniProtKB/TrEMBL
      Q793L1
      Related
      ENSMUSP00000022828.9, ENSMUST00000022828.9
      Conserved Domains (1) summary
      cd08060
      Location:6188
      MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55818976..55822832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158938.1XP_036014831.1  ER membrane protein complex subunit 9 isoform X2

      Conserved Domains (1) summary
      pfam03665
      Location:394
      UPF0172; Uncharacterized protein family (UPF0172)