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    Insig2 insulin induced gene 2 [ Mus musculus (house mouse) ]

    Gene ID: 72999, updated on 3-Dec-2024

    Summary

    Official Symbol
    Insig2provided by MGI
    Official Full Name
    insulin induced gene 2provided by MGI
    Primary source
    MGI:MGI:1920249
    See related
    Ensembl:ENSMUSG00000003721 AllianceGenome:MGI:1920249
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Insig-2; 2900053I11Rik; C730043J18Rik
    Summary
    Predicted to enable oxysterol binding activity and protein sequestering activity. Acts upstream of or within several processes, including cholesterol biosynthetic process; ear morphogenesis; and negative regulation of lipid biosynthetic process. Predicted to be part of SREBP-SCAP-Insig complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in central nervous system; jaw bone; and retina. Orthologous to human INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 40.0), large intestine adult (RPKM 16.4) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Insig2 in Genome Data Viewer
    Location:
    1 E2.3; 1 52.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (121232082..121260391, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (121304353..121332662, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cerebellum expressed regulatory RNA Neighboring gene predicted gene, 46155 Neighboring gene STARR-seq mESC enhancer starr_02073 Neighboring gene predicted gene, 41940 Neighboring gene STARR-seq mESC enhancer starr_02074 Neighboring gene STARR-positive B cell enhancer ABC_E3298 Neighboring gene RIKEN cDNA 2210011K15 gene Neighboring gene STARR-seq mESC enhancer starr_02075 Neighboring gene STARR-positive B cell enhancer ABC_E10030 Neighboring gene predicted gene, 35243

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxysterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein sequestering activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SREBP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in SREBP-SCAP complex retention in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in SREBP-SCAP complex retention in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in SREBP-SCAP complex retention in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cholesterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cranial suture morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within middle ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of steroid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to sterol depletion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within triglyceride metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SREBP-SCAP-Insig complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SREBP-SCAP-Insig complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of SREBP-SCAP-Insig complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    insulin-induced gene 2 protein
    Names
    INSIG-2 membrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271531.1NP_001258460.1  insulin-induced gene 2 protein isoform 1

      See identical proteins and their annotated locations for NP_001258460.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK050394, BC023067
      Consensus CDS
      CCDS15236.1
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
      Related
      ENSMUSP00000124345.2, ENSMUST00000159085.8
      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)
    2. NM_001271532.1NP_001258461.1  insulin-induced gene 2 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC163333
      Consensus CDS
      CCDS78670.1
      UniProtKB/TrEMBL
      A0A087WQP7
      Related
      ENSMUSP00000140292.2, ENSMUST00000186915.2
      Conserved Domains (1) summary
      pfam07281
      Location:1103
      INSIG; Insulin-induced protein (INSIG)
    3. NM_001357251.1NP_001344180.1  insulin-induced gene 2 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163333
      Consensus CDS
      CCDS15236.1
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)
    4. NM_001431287.1NP_001418216.1  insulin-induced gene 2 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
    5. NM_001431289.1NP_001418218.1  insulin-induced gene 2 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
    6. NM_001431290.1NP_001418219.1  insulin-induced gene 2 protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
    7. NM_001431291.1NP_001418220.1  insulin-induced gene 2 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/TrEMBL
      A0A087WQP7
    8. NM_001431292.1NP_001418221.1  insulin-induced gene 2 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/TrEMBL
      A0A087WQP7
    9. NM_001431293.1NP_001418222.1  insulin-induced gene 2 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/TrEMBL
      A0A087WQP7
    10. NM_001431294.1NP_001418223.1  insulin-induced gene 2 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163333
    11. NM_001431296.1NP_001418225.1  insulin-induced gene 2 protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163333
    12. NM_001431297.1NP_001418226.1  insulin-induced gene 2 protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC163333
      UniProtKB/TrEMBL
      E0CXS5
    13. NM_133748.2NP_598509.1  insulin-induced gene 2 protein isoform 1

      See identical proteins and their annotated locations for NP_598509.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AC163333, BC023067
      Consensus CDS
      CCDS15236.1
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
      Related
      ENSMUSP00000003818.8, ENSMUST00000003818.14
      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)
    14. NM_178082.3NP_835183.1  insulin-induced gene 2 protein isoform 1

      See identical proteins and their annotated locations for NP_835183.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
      Source sequence(s)
      AK040703, AY156084, BC023067
      Consensus CDS
      CCDS15236.1
      UniProtKB/Swiss-Prot
      Q3TMY2, Q8BWP1, Q91WG1
      Related
      ENSMUSP00000065485.7, ENSMUST00000071064.13
      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      121232082..121260391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529891.4XP_006529954.1  insulin-induced gene 2 protein isoform X1

      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)
    2. XM_006529892.2XP_006529955.1  insulin-induced gene 2 protein isoform X1

      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)
    3. XM_006529889.2XP_006529952.1  insulin-induced gene 2 protein isoform X1

      Conserved Domains (1) summary
      pfam07281
      Location:31211
      INSIG; Insulin-induced protein (INSIG)