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    Zfp341 zinc finger protein 341 [ Mus musculus (house mouse) ]

    Gene ID: 228807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp341provided by MGI
    Official Full Name
    zinc finger protein 341provided by MGI
    Primary source
    MGI:MGI:2682937
    See related
    Ensembl:ENSMUSG00000059842 AllianceGenome:MGI:2682937
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf341
    Summary
    Predicted to enable DNA-binding transcription activator activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in central nervous system; female associated reproductive structure; ovary; tooth; and urethra of female. Human ortholog(s) of this gene implicated in hyper IgE recurrent infection syndrome 3. Orthologous to human ZNF341 (zinc finger protein 341). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 5.0), CNS E18 (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp341 in Genome Data Viewer
    Location:
    2 H1; 2 76.79 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (154453736..154488741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154611816..154646821)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39963 Neighboring gene STARR-seq mESC enhancer starr_06130 Neighboring gene peroxisomal membrane protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E228 Neighboring gene predicted gene 14198 Neighboring gene STARR-positive B cell enhancer ABC_E7873 Neighboring gene STARR-positive B cell enhancer ABC_E6003 Neighboring gene charged multivesicular body protein 4B Neighboring gene RIKEN cDNA 9030607L20 gene Neighboring gene ribisomal protein L5, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Accelerating functional gene discovery in osteoarthritis. Butterfield NC, et al. Nat Commun, 2021 Jan 20. PMID 33473114, Free PMC Article
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Homology

    Clone Names

    • MGC73471

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 341

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199304.1 → NP_955008.2  zinc finger protein 341

      See identical proteins and their annotated locations for NP_955008.2

      Status: PROVISIONAL

      Source sequence(s)
      BC057098
      Consensus CDS
      CCDS16937.1
      UniProtKB/TrEMBL
      A2AVM0, Q6PGC9
      Related
      ENSMUSP00000080596.7, ENSMUST00000081926.13
      Conserved Domains (5) summary
      COG5048
      Location:321 → 726
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:565 → 585
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:539 → 561
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:321 → 342
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:334 → 359
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      154453736..154488741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161505.1 → XP_036017398.1  zinc finger protein 341 isoform X1

      UniProtKB/TrEMBL
      A2AVM0
      Conserved Domains (3) summary
      COG5048
      Location:313 → 718
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:557 → 577
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:531 → 553
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_004940133.1 RNA Sequence

    2. XR_374456.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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