Snx15 sorting nexin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Snx15provided by MGI
Official Full Name: sorting nexin 15provided by MGI
Primary source: MGI:MGI:1916274
See related: Ensembl:ENSMUSG00000024787 AllianceGenome:MGI:1916274
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1500032B08Rik; E130013C21Rik
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in protein transport. Predicted to be located in cytosol; nucleolus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SNX15 (sorting nexin 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 16.5), liver E14 (RPKM 14.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 4.34 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (6169429..6182446, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (6119399..6132415, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Abeta generation.
Title: SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026912.2 → NP_081188.1 sorting nexin-15

See identical proteins and their annotated locations for NP_081188.1

Status: VALIDATED

Source sequence(s)

AI850984, BC016091, BY289304

Consensus CDS

CCDS29495.1

UniProtKB/Swiss-Prot

Q91WE1

Related

ENSMUSP00000025702.8, ENSMUST00000025702.14

Conserved Domains (2) summary

cd02677
Location:267 → 337

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl02563
Location:9 → 126

PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

6169429..6182446 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531831.5 → XP_006531894.1 sorting nexin-15 isoform X1

See identical proteins and their annotated locations for XP_006531894.1

UniProtKB/Swiss-Prot

Q91WE1

Conserved Domains (2) summary

cd02677
Location:267 → 337

MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.

cl02563
Location:9 → 126

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_011248651.4 → XP_011246953.1 sorting nexin-15 isoform X2

UniProtKB/TrEMBL

D3Z479

Related

ENSMUSP00000122740.2, ENSMUST00000154601.8

Conserved Domains (1) summary

cl02563
Location:9 → 126

PX_domain; The Phox Homology domain, a phosphoinositide binding module