Cd86 CD86 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd86provided by MGI
Official Full Name: CD86 antigenprovided by MGI
Primary source: MGI:MGI:101773
See related: Ensembl:ENSMUSG00000022901 AllianceGenome:MGI:101773
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2
Summary: Predicted to enable receptor ligand activity. Involved in several processes, including positive regulation of immunoglobulin production; positive regulation of non-canonical NF-kappaB signal transduction; and toll-like receptor 3 signaling pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of T cell proliferation; and toll-like receptor signaling pathway. Located in external side of plasma membrane and intracellular membrane-bounded organelle. Is expressed in central nervous system; mandible; and retina. Used to study Guillain-Barre syndrome. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; autoimmune disease (multiple); chronic lymphocytic leukemia; chronic obstructive pulmonary disease; and systemic scleroderma. Orthologous to human CD86 (CD86 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 3.3), liver E18 (RPKM 2.8) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.72 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (36389318..36486439, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (36568956..36666158, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
Title: PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.
Title: Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.
CD86 is targeted by miR-199a-3p, thereby linking it to DC maturation. miR-199a-3p therefore directly inhibits CD86 expression via 3'-UTR targeting, subsequently prolonging allograft survival in a mouse heart transplantation model. miR-199a-3p over-expression may therefore be a potential therapeutic strategy for use in organ transplantation or patients with autoimmune diseases.
Title: MiR-199a-3p modulates the function of dendritic cells involved in transplantation tolerance by targeting CD86.
Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells
Title: Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells.
CD80/CD86 signaling plays a significant role in the initial inflammatory response to S. aureus.
Title: CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway.
Our results reveal a role for B7-2 as obligatory receptor for superantigens. B7-2 homodimer interface mimotopes prevent superantigen lethality by blocking the superantigen-host costimulatory receptor interaction.
Title: Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction.
results suggest that the TLR2-p38-CD86 signaling pathway plays a vital role in inflammation associated with burn injury
Title: TLR2 affects CD86 expression and inflammatory response in burn injury mice through regulation of p38.
role with CD40 in primary germinal center generation of distinct antigen-presenting cells
Title: Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.
The expression of CD1d showed a significantly negative correlation with CD86 level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients.
Title: Decreased CD1d level is associated with CD86 over-expression in B cells from systemic lupus erythematosus.
B7.2 expressed on skin CD8(+) T cells supports the survival of Tregs, likely through interaction with its receptor CTLA-4, which is highly expressed on skin Tregs.
Title: Cutting Edge: Skin CCR10+ CD8+ T Cells Support Resident Regulatory T Cells through the B7.2/Receptor Axis To Regulate Local Immune Homeostasis and Response.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Markers

D16Mit11 (e-PCR), detects polymorphism
- UniSTS:127737

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell anergy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in toll-like receptor 3 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-lymphocyte activation antigen CD86

Names: activation B7-2 antigen; early T cell costimulatory molecule-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.