Sfr1 SWI5 dependent recombination repair 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sfr1provided by MGI
Official Full Name: SWI5 dependent recombination repair 1provided by MGI
Primary source: MGI:MGI:1915038
See related: Ensembl:ENSMUSG00000025066 AllianceGenome:MGI:1915038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Meir5; 6330577E15Rik
Summary: Predicted to enable nuclear receptor coactivator activity. Involved in double-strand break repair via homologous recombination. Located in nucleus. Part of Swi5-Sfr1 complex. Is expressed in olfactory cortex ventricular layer; pancreas epithelium; and telencephalon ventricular layer. Orthologous to human SFR1 (SWI5 dependent homologous recombination repair protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 57.4), CNS E11.5 (RPKM 54.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D1; 19 40.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47720159..47724027)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47731714..47735588)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Swi5-Sfr1 (S5S1) stimulates Rad51-mediated homologous recombination.
Title: Swi5-Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation.
Our results thus help establish the functional relevance of the trimeric RAD51-SWI5-SFR1 complex and provide insights into the mechanistic underpinnings of homology-directed DNA repair in mammalian cells.
Title: Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination.
Biophysical evidence that the mouse Swi5-Sfr1 complex has a 1:1 stoichiometry.
Title: Rad51 presynaptic filament stabilization function of the mouse Swi5-Sfr1 heterodimeric complex.
Data show that Swi5-Sfr1 is a newly identified complex required for genomic integrity in mammalian cells with a specific role in the repair of DNA strand breaks.
Title: Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Swi5-Sfr1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Swi5-Sfr1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Swi5-Sfr1 complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: swi5-dependent recombination DNA repair protein 1 homolog

Names: DNA repair protein Sfr1; meiosis protein 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026377.2 → NP_080653.2 swi5-dependent recombination DNA repair protein 1 homolog

See identical proteins and their annotated locations for NP_080653.2

Status: VALIDATED

Source sequence(s)

AK011531, AK146810, AV335878

Consensus CDS

CCDS38019.1

UniProtKB/Swiss-Prot

Q3TH62, Q3TI03, Q3TJK0, Q3UIQ6, Q8BP27, Q8R3W0, Q9CRT7, Q9D0D7, Q9D116, Q9D4W4

UniProtKB/TrEMBL

E3WH30

Related

ENSMUSP00000096954.5, ENSMUST00000099353.6

Conserved Domains (1) summary

pfam10376
Location:108 → 310

Mei5; Double-strand recombination repair protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

47720159..47724027

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527308.4 → XP_006527371.1 swi5-dependent recombination DNA repair protein 1 homolog isoform X1

UniProtKB/TrEMBL

E3WH30

Conserved Domains (1) summary

pfam10376
Location:96 → 298

Mei5; Double-strand recombination repair protein