Them4 thioesterase superfamily member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Them4provided by MGI
Official Full Name: thioesterase superfamily member 4provided by MGI
Primary source: MGI:MGI:1923028
See related: Ensembl:ENSMUSG00000028145 AllianceGenome:MGI:1923028
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2700077M13Rik; 4921507I02Rik
Summary: Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of mitochondrial membrane permeability involved in apoptotic process. Located in mitochondrion. Is expressed in ganglia; hindbrain; and trigeminal nerve. Orthologous to human THEM4 (thioesterase superfamily member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 9.0), cerebellum adult (RPKM 7.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.51 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94217415..94239847)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (94310132..94332540)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy.
Title: Carboxyl-terminal modulator protein (CTMP) deficiency mitigates denervation-induced skeletal muscle atrophy.
Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis.
Title: Carboxyl-terminal modulator protein regulates Akt signaling during skeletal muscle atrophy in vitro and a mouse model of amyotrophic lateral sclerosis.
Increased cardiac expression of CTMP protects against cardiac hypertrophy by suppressing the protein kinase B signaling pathway.
Title: Carboxyl-Terminal Modulator Protein Ameliorates Pathological Cardiac Hypertrophy by Suppressing the Protein Kinase B Signaling Pathway.
Results suggest that Akt is phosphorylated and translocated to nucleus after traumatic brain injury (TBI) to exert neuroprotective effects; however, CTMP is simultaneously triggered to inhibit the phosphorylation of Akt
Title: Small interfering RNA directed against CTMP reduces acute traumatic brain injury in a mouse model by activating Akt.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial intermembrane space	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-coenzyme A thioesterase THEM4

Names: acyl-CoA thioesterase THEM4; carboxyl-terminal modulator protein

NP_083707.1

EC 3.1.2.2

XP_030108728.1

EC 3.1.2.2

XP_036019276.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029431.2 → NP_083707.1 acyl-coenzyme A thioesterase THEM4

See identical proteins and their annotated locations for NP_083707.1

Status: VALIDATED

Source sequence(s)

AC164562

Consensus CDS

CCDS38533.1

UniProtKB/Swiss-Prot

A3KPD5, Q3UUI3, Q8BYS9, Q8R234, Q9D5Y3

Related

ENSMUSP00000062841.8, ENSMUST00000049822.10

Conserved Domains (1) summary

cd03443
Location:134 → 221

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

94217415..94239847

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163383.1 → XP_036019276.1 acyl-coenzyme A thioesterase THEM4 isoform X1

Conserved Domains (1) summary

cd03443
Location:39 → 126

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...
XM_030252868.1 → XP_030108728.1 acyl-coenzyme A thioesterase THEM4 isoform X1

Conserved Domains (1) summary

cd03443
Location:39 → 126

PaaI_thioesterase; PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not ...