Dnah7c dynein, axonemal, heavy chain 7C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnah7cprovided by MGI
Official Full Name: dynein, axonemal, heavy chain 7Cprovided by MGI
Primary source: MGI:MGI:3639762
See related: Ensembl:ENSMUSG00000101337 AllianceGenome:MGI:3639762
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dnahc7c
Summary: Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within cilium movement and inner dynein arm assembly. Predicted to be located in cytosol. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in spermatozoon and testis. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DNAH7 (dynein axonemal heavy chain 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 4.9), CNS E18 (RPKM 0.3) and 4 other tissues See more
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Genomic context

Location:: 1 C1.1; 1 24.0 cM

Exon count:: 67

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (46464590..46846637)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (46425428..46807477)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables minus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	ISO Inferred from Sequence Orthology more info
involved_in cilium movement involved in cell motility	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in 9+2 motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of inner dynein arm	IBA Inferred from Biological aspect of Ancestor more info
part_of inner dynein arm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein, axonemal, heavy chain 7C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310335.1 → NP_001297264.1 dynein, axonemal, heavy chain 7C

Status: VALIDATED

Source sequence(s)

AC122879, AC124185, AC163216

Consensus CDS

CCDS78579.1

UniProtKB/TrEMBL

A0A087WR13, L7N1Y0

Related

ENSMUSP00000140430.2, ENSMUST00000189749.7

Conserved Domains (5) summary

pfam03028
Location:3318 → 4012

Dynein_heavy; Dynein heavy chain and region D6 of dynein motor

pfam08393
Location:759 → 1163

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12777
Location:2587 → 2933

MT; Microtubule-binding stalk of dynein motor

pfam12781
Location:2963 → 3178

AAA_9; ATP-binding dynein motor region D5

cl21455
Location:1290 → 1520

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

46464590..46846637

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238631.4 → XP_011236933.1 dynein, axonemal, heavy chain 7C isoform X1

UniProtKB/TrEMBL

L7N1Y0

Conserved Domains (6) summary

COG5245
Location:959 → 3690

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam08393
Location:757 → 1162

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1290 → 1640

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12780
Location:2335 → 2595

AAA_8; P-loop containing dynein motor region D4

pfam12781
Location:2987 → 3203

AAA_9; ATP-binding dynein motor region D5

pfam18199
Location:3744 → 4044

Dynein_C; Dynein heavy chain C-terminal domain
XM_006496387.5 → XP_006496450.1 dynein, axonemal, heavy chain 7C isoform X2

Conserved Domains (6) summary

COG5245
Location:86 → 2087

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam12774
Location:1 → 37

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam12775
Location:359 → 539

AAA_7; P-loop containing dynein motor region D3

pfam12780
Location:732 → 992

AAA_8; P-loop containing dynein motor region D4

pfam12781
Location:1384 → 1600

AAA_9; ATP-binding dynein motor region D5

pfam18199
Location:2141 → 2441

Dynein_C; Dynein heavy chain C-terminal domain