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    Lcch3 Ligand-gated chloride channel homolog 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32554, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lcch3provided by FlyBase
    Official Full Name
    Ligand-gated chloride channel homolog 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0010240
    Locus tag
    Dmel_CG17336
    See related
    AllianceGenome:FB:FBgn0010240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17336; CT38330; Dmel\CG17336; DmGABAbeta; DmGA_b; LCCH3
    Summary
    Enables GABA-gated chloride ion channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Located in plasma membrane. Is expressed in several structures, including adult antennal lobe local neurons; adult central brain; adult optic lobe; ganglia; and larval nervous system. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; autistic disorder; epilepsy (multiple); and heroin dependence. Orthologous to several human genes including GABRB1 (gamma-aminobutyric acid type A receptor subunit beta1) and GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lcch3 in Genome Data Viewer
    Location:
    14A1-14A1; 1-52 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15925105..15928529)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15819138..15822562)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 4 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45000 Neighboring gene Ranbp16 Neighboring gene Stromal interaction molecule Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster. Henderson JE, et al. Biochem Biophys Res Commun, 1993 Jun 15. PMID 7685594
    2. Distribution of two GABA receptor-like subunits in the Drosophila CNS. Aronstein K, et al. Invert Neurosci, 1996 Sep. PMID 9372158
    3. Subunit composition determines picrotoxin and bicuculline sensitivity of Drosophila gamma-aminobutyric acid receptors. Zhang HG, et al. Mol Pharmacol, 1995 Nov. PMID 7476913
    4. PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogaster. Henderson JE, et al. Insect Biochem Mol Biol, 1994 Apr. PMID 8025558
    5. GABAergic regulation of locomotion before and during an ethanol exposure in Drosophila melanogaster. Daack CW, et al. Behav Brain Res, 2021 Jul 23. PMID 34015397

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GABA-gated chloride ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ligand-gated chloride channel homolog 3
    Names
    CG17336-PC
    GABA receptor beta subunit
    Lcch3-PC
    beta subunit
    ligand-gated chloride channel
    ligand-gated chloride channel homologue 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15925105..15928529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206746.2 → NP_996469.1  Ligand-gated chloride channel homolog 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996469.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4J6, Q08832, Q9TX49, Q9VXL8
      Conserved Domains (3) summary
      TIGR00860
      Location:15 → 493
      LIC; Cation transporter family protein
      pfam02931
      Location:47 → 256
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:263 → 490
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08832.2 Q08832

    Gene LinkOut

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