Stim Stromal interaction molecule [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Stimprovided by FlyBase
Official Full Name: Stromal interaction moleculeprovided by FlyBase
Primary source: FLYBASE:FBgn0045073
Locus tag: Dmel_CG9126
See related: AllianceGenome:FB:FBgn0045073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: C-Stim; CG9126; D-Stim; D-STIM; Dmel\CG9126; dstim; dStim; dSTIM; stim; STIM; stim1; STIM1
Summary: Enables calcium ion binding activity; calcium-induced calcium release activity; and store-operated calcium channel activity. Involved in several processes, including chaeta development; detection of calcium ion; and store-operated calcium entry. Located in endoplasmic reticulum-plasma membrane contact site. Is expressed in several structures, including adult head; ectoderm; embryonic/larval midgut primordium; epithelial furrow; and imaginal disc. Used to study dilated cardiomyopathy; hypertrophic cardiomyopathy; and obesity. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to several human genes including STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 14A1-14A1; 1-52 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15934495..15940451, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15828528..15834484, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.
Title: Chronic dysfunction of Stromal interaction molecule by pulsed RNAi induction in fat tissue impairs organismal energy homeostasis in Drosophila.
We find two STIM-regulated peptides, Corazonin and short Neuropeptide F, to be required for NR larvae to complete development. Further, a set of secretory DLP (Dorso lateral peptidergic) neurons which co-express both peptides was identified
Title: ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.
These data identify an essential role for STIM in larval dopaminergic cells.
Title: CRISPR-Cas-Induced Mutants Identify a Requirement for dSTIM in Larval Dopaminergic Cells of Drosophila melanogaster.
after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry.
Title: Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.
Data indicate that STIM functions as sensors of Ca2+ stored in the endoplasmic reticulum (ER) lumen and translocate into ER-PM (plasma membrane) junctions to tether and activate Orai channels when ER Ca2+ concentration decreases.
Title: Orai channel pore properties and gating by STIM: implications from the Orai crystal structure.
Induced STIM1 translocation to the plasma membrane promotes intestinal epithelial cell migration after wounding by enhancing TRPC1-mediated Ca2+ signaling and provide new insight into the mechanism of intestinal epithelial restitution.
Title: STIM1 translocation to the plasma membrane enhances intestinal epithelial restitution by inducing TRPC1-mediated Ca2+ signaling after wounding.
dSTIM regulates growth and patterning of imaginal discs and indicate potential interactions with the Notch and Wingless signaling pathways.
Title: The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning.
Interaction with the C terminus of Stim thus induces Orai dimers to dimerize, forming tetramers that constitute the Ca(2+)-selective pore.
Title: The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers.
proposal that STIM1 functions as the missing link between Ca2+ store depletion and store-operated calcium influx, serving as a Ca2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels
Title: STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-induced calcium release activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-plasma membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stromal interaction molecule

Names: CG9126-PA; CG9126-PD; CG9126-PF; CG9126-PG; Stim-PA; Stim-PD; Stim-PF; Stim-PG; drosophila stromal interaction molecule; stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

15934495..15940451 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206747.3 → NP_996470.2 stromal interaction molecule, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996470.2

Status: REVIEWED

UniProtKB/TrEMBL

C7LAI2, H1UUK4, Q7KUZ1

Conserved Domains (5) summary

cd09504
Location:209 → 282

SAM_STIM-1,2-like; SAM domain of STIM-1,2-like proteins

smart00454
Location:210 → 271

SAM; Sterile alpha motif

pfam16533
Location:410 → 507

SOAR; STIM1 Orai1-activating region

cd16269
Location:360 → 372

GBP_C; coiled coil [structural motif]

cl20817
Location:312 → 392

GBP_C; Guanylate-binding protein, C-terminal domain
NM_078633.4 → NP_523357.2 stromal interaction molecule, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523357.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P83094

UniProtKB/TrEMBL

C7LAI2

Related

FBpp0073955

Conserved Domains (5) summary

cd09504
Location:209 → 282

SAM_STIM-1,2-like; SAM domain of STIM-1,2-like proteins

smart00454
Location:210 → 271

SAM; Sterile alpha motif

pfam16533
Location:410 → 507

SOAR; STIM1 Orai1-activating region

cd16269
Location:360 → 372

GBP_C; coiled coil [structural motif]

cl20817
Location:312 → 392

GBP_C; Guanylate-binding protein, C-terminal domain
NM_001258774.2 → NP_001245703.1 stromal interaction molecule, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245703.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF82
NM_001298380.1 → NP_001285309.1 stromal interaction molecule, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285309.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF82