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    gNacalpha germinal nascent polypeptide-associated complex alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33279, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gNacalphaprovided by FlyBase
    Official Full Name
    germinal nascent polypeptide-associated complex alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031296
    Locus tag
    Dmel_CG4415
    See related
    AllianceGenome:FB:FBgn0031296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4415; Dmel\CG4415; gNAC-alpha; gNACalpha
    Summary
    Enables ribosome binding activity. Predicted to be involved in protein targeting to membrane. Part of nascent polypeptide-associated complex. Is expressed in adult head; fat body/gonad primordium; germline cell; and gonad. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See gNacalpha in Genome Data Viewer
    Location:
    21E3-21E3; 2-1.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1037246..1038685)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1037246..1038685)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44801 Neighboring gene antisense RNA:CR46486 Neighboring gene IA-2 protein tyrosine phosphatase Neighboring gene uncharacterized protein Neighboring gene Star Neighboring gene asteroid

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extended disordered regions of ribosome-associated NAC proteins paralogs belong only to the germline in Drosophila melanogaster. Kogan GL, et al. Sci Rep, 2022 Jul 1. PMID 35778515, Free PMC Article
    2. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Eulalio A, et al. Mol Cell Biol, 2007 Jun. PMID 17403906, Free PMC Article
    3. Integrative analysis unveils new functions for the Drosophila Cutoff protein in noncoding RNA biogenesis and gene regulation. Pritykin Y, et al. RNA, 2017 Jul. PMID 28420675, Free PMC Article
    4. Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster. Shigenobu S, et al. Proc Natl Acad Sci U S A, 2006 Sep 12. PMID 16950879, Free PMC Article
    5. A transcriptome-wide RNAi screen in the Drosophila ovary reveals factors of the germline piRNA pathway. Czech B, et al. Mol Cell, 2013 Jun 6. PMID 23665227, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    germinal nascent polypeptide-associated complex alpha subunit
    Names
    CG4415-PA
    CG4415-PB
    gNacalpha-PA
    gNacalpha-PB
    germinal NAC-alpha subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      1037246..1038685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134717.4 → NP_608561.2  germinal nascent polypeptide-associated complex alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608561.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4F0, Q9VPV7
      Related
      FBpp0077616
      Conserved Domains (3) summary
      COG1308
      Location:193 → 345
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:309 → 345
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:194 → 244
      NAC; NAC domain

    2. NM_001169379.2 → NP_001162850.1  germinal nascent polypeptide-associated complex alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4F0, Q9VPV7
      Conserved Domains (3) summary
      COG1308
      Location:193 → 345
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14358
      Location:309 → 345
      UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes
      pfam01849
      Location:194 → 244
      NAC; NAC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPV7 Q9VPV7

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