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    CG8520 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36357, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8520provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033734
    Locus tag
    Dmel_CG8520
    See related
    AllianceGenome:FB:FBgn0033734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8520; FBgn 33734
    Summary
    Predicted to enable ATP hydrolysis activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and mitochondrion organization. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human AFG1L (AFG1 like ATPase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8520 in Genome Data Viewer
    Location:
    49A4-49A4; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12422931..12425459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8310436..8312964)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Deoxyribose-phosphate aldolase Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 54kD Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Some novel intron positions in conserved Drosophila genes are caused by intron sliding or tandem duplication. Lehmann J, et al. BMC Evol Biol, 2010 May 26. PMID 20500887, Free PMC Article
    2. Network analyses reveal novel aspects of ALS pathogenesis. Sanhueza M, et al. PLoS Genet, 2015 Mar. PMID 25826266, Free PMC Article
    3. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Blanco E, et al. Genome Biol, 2008. PMID 18783608, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8520-PA
    CG8520-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12422931..12425459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136936.5 → NP_610780.1  uncharacterized protein Dmel_CG8520, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4T8
      Related
      FBpp0087037
      Conserved Domains (2) summary
      COG1485
      Location:22 → 450
      YhcM; Predicted ATPase [General function prediction only]
      cl21455
      Location:31 → 450
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001201982.2 → NP_001188911.1  uncharacterized protein Dmel_CG8520, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188911.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K4T8
      Conserved Domains (2) summary
      COG1485
      Location:22 → 450
      YhcM; Predicted ATPase [General function prediction only]
      cl21455
      Location:31 → 450
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K4T8 Q7K4T8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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